ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Artificial Intelligence in Physical Sciences: Symbolic Regression Trends and Perspectives. [PDF]
Arch Comput Methods Eng, 2023 Angelis D, Sofos F, Karakasidis TE.
europepmc +1 more source
Polyelectrolyte Design Principles for Electrophoretic Drug Delivery
Advanced Science, EarlyView.Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo +8 more
wiley +1 more source
Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis
Advanced Science, EarlyView.Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang +9 more
wiley +1 more source
SymRefine: A symbolic regression approach for refining and compressing neural networks. [PDF]
Neurocomputing (Amst)Wei W, Lu Q, Huang C, Lee D, Luo J.
europepmc +1 more source
Fluid Properties Extraction in Confined Nanochannels with Molecular Dynamics and Symbolic Regression Methods. [PDF]
Micromachines (Basel), 2023 Angelis D +3 more
europepmc +1 more source
Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity
Advanced Science, EarlyView.This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini +8 more
wiley +1 more source
Data-Informed Model Complexity Metric for Optimizing Symbolic Regression Models [PDF]
Nathan Haut, Zenas Huang, Adam Alessio
openalex +1 more source
A flexible symbolic regression method for constructing interpretable clinical prediction models. [PDF]
NPJ Digit Med, 2023 La Cava WG +7 more
europepmc +1 more source
Advanced Science, EarlyView.A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li +6 more
wiley +1 more source