Results 181 to 190 of about 17,106 (295)

A flexible symbolic regression method for constructing interpretable clinical prediction models. [PDF]

open access: yesNPJ Digit Med, 2023
La Cava WG   +7 more
europepmc   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun   +19 more
wiley   +1 more source

Scalable Neural Symbolic Regression using Control Variables

open access: yes
Symbolic regression (SR) is a powerful technique for discovering the analytical mathematical expression from data, finding various applications in natural sciences due to its good interpretability of results.
Qi, Hairong   +5 more
core  

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang   +11 more
wiley   +1 more source

Contemporary Symbolic Regression Methods and their Relative Performance. [PDF]

open access: yesAdv Neural Inf Process Syst, 2021
La Cava W   +7 more
europepmc   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

open access: yesAdvanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang   +6 more
wiley   +1 more source

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