Results 201 to 210 of about 1,150,344 (284)

Who Qualifies to Assure? The Professional and Managerial Capture of Sustainability Assurance

open access: yesBusiness Strategy and the Environment, EarlyView.
ABSTRACT This study examines how the qualification of assurors in sustainability and environmental reporting assurance (SERA) is constructed and why it remains fiercely contested. Drawing on actor–network theory (ANT) and qualitative evidence from regulators, NGOs, assurors and reporting companies in India, we conceptualise ‘qualification’ as a ...
Flavia Rodricks   +2 more
wiley   +1 more source

The Age of Questions: Truth Regimes and Subjectivity in the Era of Large Language Models

open access: yesBehavioral Sciences &the Law, EarlyView.
ABSTRACT This essay explores how digital technologies shape subjectivity's infra‐political constitution, focusing on large language models (LLMs) like ChatGPT or Gemini within what philosophers, inspired by Michel Foucault, term the “digital truth regime.” After defining this regime, the essay identifies five key traits of LLMs: presentism in truth ...
Charles Corval
wiley   +1 more source

Updated facility‐level inventory and LCIA of the public electricity grid in Ontario, Canada

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
Abstract As the composition of Ontario's electricity grid will change over time, it is important to have a comprehensive understanding of the environmental impacts of Ontario's electricity grid as it stands today. However, publicly available information on impacts of Ontario's electricity grid is available only in aggregate from government sources.
Jamie Rose   +2 more
wiley   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

open access: yesCytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith   +9 more
wiley   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses to Support Cofetuzumab Pelidotin (ABBV‐647) Dose Optimization in Non‐Small Cell Lung Cancer Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf   +8 more
wiley   +1 more source

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