Results 81 to 90 of about 338,011 (348)

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Declaraciones de Deseo y Declaraciones de Realidad : State-Indigenous Relations and Intercultural-Bilingual Education in Peru and Guatemala [PDF]

, 2011
Ethnic diversity has historically created conflict in many nation-states throughout the globe. From the era of nation-state formation to the present, states have had various strategies for dealing with this diversity. These strategies can be divided into
Christie, Emily
core   +1 more source

“It's only sport” - the symbolic neutralization of “violence” [PDF]

, 2016
Within the commodified world of professional ice hockey, athletes sell their bodily performances in return for a salary. A central feature of this transaction is the very real risk of physical injury – a risk inherent within most contact sports, but ...
Abercrombie, Atkinson, Atkinson, Baudrillard, Biasca, Bredemeier, Brohm, Caillois, Carter, Carter, Chancer, Chaney, Channon, Channon, Crawford, Daly, Debord, Dunning, Dunning, Dunning, Elias, Elias, Emery, Gard, Geertz, Goffman, Goffman, Gray, Gruneau, Guttman, Hargreaves, Hock, Hughes, Jakubowska, Jary, Katz, King, Kleinplatz, Lasch, Lyng, Maguire, Maguire, Malcolm, Matthews, Matthews, Matthews, Merk, Messner, Pringle, Rigauer, Robidoux, Sims, Smith, Smith, Sparkes, Sugden, Sykes, Tator, Tegner, Thing, Turner, Young, Young, Young   +63 more
core   +2 more sources

Ascites circRNA ASCOR Drives Platinum Resistance of High‐Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation

Advanced Science, EarlyView.
High‐grade serous ovarian carcinoma (HGSOC) is plagued by platinum resistance, with malignant ascites closely linked to poor outcomes. Here, we identify ASCOR, a circRNA enriched in ascites small extracellular vesicles (sEVs) from platinum‐resistant HGSOC patients, as a predictor of poor survival. ASCOR enhances platinum resistance in vitro and in vivo
Hanyuan Liu, Chenchen Zhu, Xuelin Yao, Yi Liu, Jing Zhu, Yuebo Li, Hanjie Xu, Cheng Peng, Ge Shan, Liang Chen, Ying Zhou   +10 more
wiley   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

THE WALL: SYMBOLIC ASPECTS OF VIOLENCE IN EDUCATION

Travessias, 2011
This article addresses the issue of symbolic domination, especially the symbolic violence related to Education. As a support we have the theoretical studies of the French philosopher Pierre Bourdieu (1994, 1998 and 2007).
Cínthia Morelli Rosa
doaj  

Expressions of the Violence in School: Ruptures and challenges at debate

Fronteiras: Journal of Social, Technological and Environmental Science, 2014
This research aimed to analyse how children represent the violence in school and the impact of this experience of violence in relations that arise in the school context. To achieve this study we used data from a qualitative research (Lüdke and André 1986)
Sheila Daniela Medeiros Santos
doaj   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, EarlyView.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis

Advanced Science, EarlyView.
Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan, Yunping Chen, Wei Zhou, Yanghong Xu, Junran Huang, Yi Chen, Jizhou Meng, Guoxin Yao, Wenchao Huang   +8 more
wiley   +1 more source

THE WALL: SYMBOLIC ASPECTS OF VIOLENCE IN EDUCATION

Travessias, 2010
This article addresses the issue of symbolic domination, especially the symbolic violence related to Education. As a support we have the theoretical studies of the French philosopher Pierre Bourdieu (1994, 1998 and 2007).
Cínthia Morelli Rosa
doaj