Results 191 to 200 of about 1,980,475 (297)

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

The differential toxicity of three different oxidized nickel compound nanoparticles and the effects of particle surface ligands in mouse alveolar macrophages. [PDF]

Toxicol Sci
Kendall RL, Hamilton RF, Albright JM, Zhao Y, Hang Y, Tang C, Porter D, Wu N, Holian A.   +8 more
europepmc   +1 more source

SiO2‐CaOCME/Poly(Tetrahydrofuran)/Poly(Caprolactone) 3D‐Printed Scaffolds Drive Human‐Bone Marrow Stromal Cell Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory, Agathe C.M. Heyraud, Julian R. Jones, Sara M. Rankin   +3 more
wiley   +1 more source

Exchange of Dual Clumped Isotopes of CO₂ With the Phosphoric Acid-Water System. [PDF]

Rapid Commun Mass Spectrom
Swart PK, Lu C.
europepmc   +1 more source

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addiction. [PDF]

Elife
Chittajallu R, Vlachos A, Caccavano AP, Yuan X, Hunt S, Abebe D, London E, Pelkey KA, McBain CJ.   +8 more
europepmc   +1 more source

A Biomimetic Buffering Hydrogel Scaffold for Long‐Term Culture of Patient‐Derived Tumor Organoids

Advanced Healthcare Materials, EarlyView.
A biomimetic fibrous buffering hydrogel controls the local acidification at the tumoroid/hydrogel interface at the physiologically relevant level over 21‐day culture. The buffering effect promotes cancer cell proliferation in the tumoroids and supports the structural integrity and mechanical properties of the hydrogel scaffold over long‐term tumoroid ...
Elizaveta Gusarova, Fatemeh Ahmadi, Jennifer Cruickshank, Zheyuan Miao, Mariia Moshkova, Iuliia Pilipenko, David W. Cescon, Eugenia Kumacheva   +7 more
wiley   +1 more source

CD36 serves as a signaling receptor and free fatty acid (FFA) transporter in dyslipidemia: the role of dapagliflozin and alirocumab in downregulating atherogenic dyslipidemia via FFA uptake inhibition-experimental study. [PDF]

Int J Surg
Yeh JN, Wang YT, Lan XW, Chen YL, Huang CR, Shao PL, Yip HK, Guo J.   +7 more
europepmc   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer. [PDF]

Front Immunol
Sánchez-Menéndez C, Rodríguez-Pérez J, Fuertes D, Leguizamon V, González-Sanmartín M, Mateos E, Cervero M, San José E, Sanz G, Álvaro E, Ballestero-Pérez A, Martí-Gallostra M, Rueda JA, Hurtado-Caballero E, Pastor C, Balaguer F, Spinelli A, Martínez-Laso J, Torres M, Perea J, Coiras M.   +20 more
europepmc   +1 more source