Results 41 to 50 of about 373,006 (268)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Geomorphism, Archetypes and Symbols in Architecture
Agathón, 2017 This paper is a revision with updating of an essay on the theme Nature and Architecture, published in 1999. Here, with the support of other disciplines, there are some similarities between natural forms and architectural forms.
Paolo Portoghesi
doaj +1 more source
Symbolic Behavior in Regular Classrooms: A Specification of Symbolic and Non-Symbolic Behavior [PDF]
Frontiers in Psychology, 2011 Students' capabilities to use symbolic information in classroom setting could be expected to influence their possibilities to be active and participating. The development of strategies for teachers to compensate for reduced capability need specific operational definition of symbolic behavior.
Billinger, Stefan, Norlander, Torsten
openaire +5 more sources
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
SYMBOLISM AND ISLAMIC VALUES IN STUDENTS’ REOG STAGE AT MUHARAM CELEBRATION
Jurnal Dakwah Risalah, 2021 Signs, symbols, and meanings are important elements in human interaction. This research aims to reveal how the signs, symbols, and meanings related and can be used to describe the relationship among students in Reog culture staging.
Muslih Aris Handayani
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
LINGUISTIC BASES OF MATAPOETHICS OF TENNESSE WILLIAMS’ DRAMATIC TEXT
Вестник Северо-Кавказского федерального университета, 2022 In this article we analyze dramatic level of Tennessee Williams’ metapoethics. As a result we have revealed author’s opinion on creative work, process of writing, importance of a word and symbols in a dramatic work.
Vyacheslav Petrovich Khodus +1 more
doaj
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source