Results 41 to 50 of about 154,622 (268)

Subgroups of Infinite Symmetric Groups

Journal of the London Mathematical Society, 1990
Various questions are discussed on the subgroup structure of \(S:=Sym(\Omega)\), where \(\Omega\) is an infinite set. It is shown that S is not the union of a chain of size \(| \Omega |\) of proper subgroups, and results are obtained on the size of the smallest families of proper subgroups with set-theoretic union S.
Macpherson, H, Neumann, P
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Hypercontractivity on the symmetric group

Forum of Mathematics, Sigma
AbstractThe hypercontractive inequality is a fundamental result in analysis, with many applications throughout discrete mathematics, theoretical computer science, combinatorics and more. So far, variants of this inequality have been proved mainly for product spaces, which raises the question of whether analogous results hold over non-product domains.We
Filmus, Yuval, Kindler, Guy, Lifshitz, Noam, Minzer, Dor   +3 more
openaire   +4 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Symmetric groups and expander graphs [PDF]

Inventiones mathematicae, 2007
We construct explicit generating sets S_n and \tilde S_n of the for the alternating and the symmetric groups, which turn the Cayley graphs C(Alt(n), S_n) and C(Sym(n), \tilde S_n) into a family of bounded degree expanders for all n. This answers affirmatively an old question which has been asked many times in the literature.
openaire   +3 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Symmetric and permutational generating set of the groups Akn+1 and Skn+1 using Sn and an element of order k

International Journal of Mathematics and Mathematical Sciences, 1998
In this paper we will show how to generate Akn+1 and Skn+1 using a copy of Sn and an element of order k in Akn+1 and Skn+1 respectively, for all positive integers n≥2 and all positive integers k≥2. We will also show how to generate Akn+1 and Skn+1
Ibraham R. Al-Amri
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source