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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov +2 more
wiley +1 more source

Characters of symmetric groups in terms of free cumulants and Frobenius coordinates [PDF]

Discrete Mathematics & Theoretical Computer Science, 2009
Free cumulants are nice and useful functionals of the shape of a Young diagram, in particular they give the asymptotics of normalized characters of symmetric groups $\mathfrak{S}(n)$ in the limit $n \to \infty$.
Maciej Dolega, Valentin Féray, Piotr Sniady +2 more
doaj +1 more source

Hypercontractivity on the symmetric group

Forum of Mathematics, Sigma
AbstractThe hypercontractive inequality is a fundamental result in analysis, with many applications throughout discrete mathematics, theoretical computer science, combinatorics and more. So far, variants of this inequality have been proved mainly for product spaces, which raises the question of whether analogous results hold over non-product domains.We
Filmus, Yuval +3 more
openaire +4 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel +2 more
wiley +1 more source

Compact Lie Groups, Generalised Euler Angles, and Applications

Universe, 2022
This is mainly a review of an intense 15-year long collaboration between the authors on explicit realisations of compact Lie groups and their applications.
Sergio Luigi Cacciatori, Antonio Scotti
doaj +1 more source

On solutions of “equations in symmetric groups”

Journal of Combinatorial Theory, Series A, 1978
AbstractLet x ϵ Sn, the symmetric group on n symbols. Let θ ϵ Aut(Sn) and let the automorphim order of x with respect to θ be defined by γθ(x)=min{k:x xθ xθ2 ⋯ xθk−1=1} where xθ is the image of x under θ. Let αg ϵ Aut(Sn) denote conjugation by the element g ϵ Sn.
Harold Finkelstein, K. I. Mandelberg
openaire +3 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source

Symmetric and permutational generating set of the groups Akn+1 and Skn+1 using Sn and an element of order k

International Journal of Mathematics and Mathematical Sciences, 1998
In this paper we will show how to generate Akn+1 and Skn+1 using a copy of Sn and an element of order k in Akn+1 and Skn+1 respectively, for all positive integers n≥2 and all positive integers k≥2. We will also show how to generate Akn+1 and Skn+1
Ibraham R. Al-Amri
doaj +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source

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