Results 51 to 60 of about 429,972 (288)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CPD-Structured Multivariate Polynomial Optimization

Frontiers in Applied Mathematics and Statistics, 2022
We introduce the Tensor-Based Multivariate Optimization (TeMPO) framework for use in nonlinear optimization problems commonly encountered in signal processing, machine learning, and artificial intelligence.
Muzaffer Ayvaz, Muzaffer Ayvaz, Lieven De Lathauwer, Lieven De Lathauwer   +3 more
doaj   +1 more source

A Novel Symmetric Four Dimensional Polytope Found Using Optimization Strategies Inspired by Thomson's Problem of Charges on a Sphere [PDF]

, 2006
Inspired by, and using methods of optimization derived from classical three dimensional electrostatics, we note a novel beautiful symmetric four dimensional polytope we have found with 80 vertices.
Altschuler, Eric Lewin, Perez-Garrido, Antonio, Stong, Richard   +2 more
core   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Neighborhood preserving sparse representation based on Nyström method for image set classification on symmetric positive definite matrices

Journal of Algorithms & Computational Technology, 2019
In the field of pattern recognition, using the symmetric positive-definite matrices to represent image set has been widely studied, and sparse representation-based classification algorithm on the symmetric positive-definite matrix manifold has attracted ...
Chu Li, Xiao-Jun Wu
doaj   +1 more source

Projected seniority-two orbital optimization of the Antisymmetric Product of one-reference orbital Geminal

, 2014
We present a new, non-variational orbital-optimization scheme for the Antisymmetric Product of one-reference orbital Geminal wave function. Our approach is motivated by the observation that an orbital-optimized seniority-zero configuration interaction ...
Abramowitz M., Dimitri Van Neck, Katharina Boguslawski, Lefebvre R., Ortiz J. V., Patrick Bultinck, Paul A. Johnson, Paul W. Ayers, Paweł Tecmer, Peter A. Limacher, Stijn De Baerdemacker   +10 more
core   +1 more source

Optimal orthogonal approximations to symmetric tensors cannot always be chosen symmetric

CoRR, 2019
We study the problem of finding orthogonal low-rank approximations of symmetric tensors. In the case of matrices, the approximation is a truncated singular value decomposition which is then symmetric. Moreover, for rank-one approximations of tensors of any dimension, a classical result proven by Banach in 1938 shows that the optimal approximation can ...
Oscar Mickelin, Sertac Karaman
openaire   +2 more sources

Well-Posedness and Porosity for Symmetric Optimization Problems [PDF]

Symmetry, 2021
In the present work, we investigate a collection of symmetric minimization problems, which is identified with a complete metric space of lower semi-continuous and bounded from below functions. In our recent paper, we showed that for a generic objective function, the corresponding symmetric optimization problem possesses two solutions. In this paper, we
openaire   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Investigation of Utilizing a Secant Stiffness Matrix for 2D Nonlinear Shape Optimization and Sensitivity Analysis [PDF]

Civil Engineering Infrastructures Journal, 2016
In this article the general non-symmetric parametric form of the incremental secant stiffness matrix for nonlinear analysis of solids have been investigated to present a semi analytical sensitivity analysis approach for geometric nonlinear shape ...
Asghar Vatani Oskouie, Amin Havaran
doaj   +1 more source