Results 241 to 250 of about 8,373 (339)
FAM20A variants cause AI1G, marked by enamel defects, gingival overgrowth and ectopic calcifications. RNA sequencing of patient‐derived gingival fibroblasts showed dysregulated genes in adhesion, proliferation and signalling pathways. Functional assays revealed increased cell proliferation, impaired ECM interactions and osteogenesis, suggesting FAM20A ...
Kanokwan Sriwattanapong +9 more
wiley +1 more source
Augmented Cardiac Inotropy by Phosphodiesterase Inhibition Requires Phosphorylation of Rad and Increased Calcium Current. [PDF]
Katchman AN +13 more
europepmc +1 more source
Abstract Glucocorticoids (GCs) are widely utilised for the treatment of inflammatory and autoimmune conditions but often precipitate significant hyperglycaemia. People with type 1 diabetes (PWT1D) may be particularly affected due to the challenges of adjusting insulin dosing, for which recommendations remain unclear.
Alexandra Katz +8 more
wiley +1 more source
Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2. [PDF]
Redeker KM +4 more
europepmc +1 more source
Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell +4 more
wiley +1 more source
The growing health burden of heat waves with focus on respiratory effects. [PDF]
Sundar KM +4 more
europepmc +1 more source

