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Communication Membrane Systems with Active Symports [PDF]
Journal of Automata, Languages and Combinatorics, 2006 Journal of Automata, Languages and Combinatorics, Volume 11, Number 3, 2006, 241 ...
Brijder, Robert +4 more
openaire +2 more sources
Chloride binding site of neurotransmitter sodium symporters [PDF]
Proceedings of the National Academy of Sciences, 2013 Neurotransmitter:sodium symporters (NSSs) play a critical role in signaling by reuptake of neurotransmitters. Eukaryotic NSSs are chloride-dependent, whereas prokaryotic NSS homologs like LeuT are chloride-independent but contain an acidic residue (Glu290 in LeuT) at a site where eukaryotic NSSs have a serine.
A. K. Kantcheva +7 more
openaire +4 more sources
Iodine status in Turkish populations and exposure to iodide uptake inhibitors. [PDF]
PLoS ONE, 2014 Perchlorate, nitrate, and thiocyanate are competitive inhibitors of the sodium iodide symporter of the thyroid membrane. These inhibitors can decrease iodine uptake by the symporter into the thyroid gland and may disrupt thyroid function.
Aysel Ozpinar +14 more
doaj +1 more source
Nature Communications, 2016 UapA is a uric acid/xanthine H+symporter from a filamentous fungus. Here, the authors solve the crystal structure of the transporter in complex with xanthine revealing it to be a dimer, and this homodimerisation is proposed to be important for function.
Yilmaz Alguel +12 more
doaj +1 more source
P Systems with Symport/Antiport of Rules
, 2004 JUCS - Journal of Universal Computer Science Volume Nr.
Cavaliere M., Genova D.
openaire +4 more sources
General Principles of Secondary Active Transporter Function [PDF]
, 2019 Transport of ions and small molecules across the cell membrane against electrochemical gradients is catalyzed by integral membrane proteins that use a source of free energy to drive the energetically uphill flux of the transported substrate. Secondary active transporters couple the spontaneous influx of a "driving" ion such as Na$^+$ or H$^+$ to the ...
arxiv +1 more source
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Tumor microenvironment affects exogenous sodium/iodide symporter expression
Translational Oncology, 2021 For decades, sodium/iodide symporter NIS-mediated iodide uptake has played a crucial role in the radioactive ablation of thyroid cancer cells. NIS-based gene therapy has also become a promising tool for the treatment of tumors of extrathyroidal origin ...
Fabio Castillo-Rivera +9 more
doaj
Advanced Science, EarlyView.This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li +3 more
wiley +1 more source
Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells
Nature Communications, 2018 Adoptive transfer of chimeric antigen receptor (CAR) T cells has shown promising anticancer results in clinical trials. Here the authors use the human sodium iodide symporter (hNIS) as a reporter gene to image human CAR T cells in cancer-bearing mice ...
Nia Emami-Shahri +7 more
doaj +1 more source