Results 81 to 90 of about 15,584 (224)

PtrVINV2 is dispensable for cellulose synthesis but essential for salt tolerance in Populus trichocarpa Torr. and Gray

Plant Biotechnology Journal, EarlyView.
Summary Invertase (EC.3.2.1.26), a key enzyme in sucrose breakdown, is crucial for cellulose synthesis. However, the function of the vacuolar invertase (VINV) in woody plants remains unclear. In this study, transgenic lines of Populus trichocarpa Torr. and Gray were generated to investigate the role of PtrVINV2 in wood formation and under high salinity
Shuang Zhang, Lina Cao, Danyang Chen, Ruhui Chang, Jiayu Cao, Qiaoyi Zhang, Yeling Qin, Guanjun Liu, Zhiru Xu   +8 more
wiley   +1 more source

Identification of potential cell surface targets in patient‐derived cultures toward photoimmunotherapy of high‐grade serous ovarian cancer

Photochemistry and Photobiology, EarlyView.
Through mRNA sequencing, proteomics, and flow cytometry, we identified potential cell surface targets toward tumor‐targeted, activatable photoimmunotherapy (taPIT) in advanced high‐grade serous ovarian cancers (HGSOCs) with low EGFR expression. The reliance on EGFR overexpression has been a major limitation of taPIT, which this study seeks to address ...
Sudip Timilsina, Anish Raju Amara, Rafay Abu, Bryan Q. Spring   +3 more
wiley   +1 more source

Identification of a sodium-bicarbonate symport in human platelets

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1996
Intracellular pH (pH(i)) was measured in human platelets using fluorescent probes. Basal pH(i) was higher in HC(O3-)- buffered solutions (7(7.33 +/- 0.01) than in nominally HCO3- free, Hepes buffered solutions (7.16 +/- 0.01, P < 0.05). Addition of EIPA caused to fall in Hepes, but did not inhibit the increase of pH(i) when platelets maintained in ...
Oscar A. Gende, Horacio E. Cingolani
openaire   +3 more sources

Reporter gene-engineering of human induced pluripotent stem cells during differentiation renders in vivo traceable hepatocyte-like cells accessible

Stem Cell Research, 2019
Primary hepatocyte transplantation (HTx) is a safe cell therapy for patients with liver disease, but wider application is circumvented by poor cell engraftment due to limitations in hepatocyte quality and transplantation strategies. Hepatocyte-like cells
Candice Ashmore-Harris, Samuel JI Blackford, Benjamin Grimsdell, Ewelina Kurtys, Marlies C Glatz, Tamir S Rashid, Gilbert O Fruhwirth   +6 more
doaj  

Deciphering the Role of Putative Novel miRNAs Encoded From the Newly Found Genomic Regions of T2T‐CHM13 in the Progression of Collecting Duct Renal Cell Carcinoma

Cancer Medicine, Volume 14, Issue 9, May 2025.
We identified 156 novel miRNAs through de novo prediction in the newly discovered genomic regions of T2T‐CHM13. These miRNAs target 345 protein‐coding genes that are downregulated in collecting duct renal cell carcinoma (cdRCC). The miRNAs may play a role in the disease by altering several key tumor suppressor pathways and targeting multiple tumor ...
Anik Mojumder, Sazzad Shahrear, Abul Bashar Mir Md. Khademul Islam   +2 more
wiley   +1 more source

Unilateral breast uptake of Tc-99m pertechnetate in a patient with cold nodule of the thyroid

World Journal of Nuclear Medicine, 2012
Common causes of unilateral breast uptake of Tc-99m pertechnetate are predominant breast-feeding on one side, mastitis, and breast cancer. Uptake of Tc-99m pertechnetate in the epithelial cells of the breast, like that of iodide, depends on the ...
Shankaramurthy Gayana, Anish Bhattacharya, Koramadai Kamaleshwaran, Bhagwant Mittal   +3 more
doaj   +1 more source

Structure and Mechanism of the Divalent Anion/Na+ Symporter [PDF]

International Journal of Molecular Sciences, 2019
Integral membrane proteins of the divalent anion/Na+ symporter (DASS) family are conserved from bacteria to humans. DASS proteins typically mediate the coupled uptake of Na+ ions and dicarboxylate, tricarboxylate, or sulfate. Since the substrates for DASS include key intermediates and regulators of energy metabolism, alterations of DASS function ...
openaire   +2 more sources

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, Volume 49, Issue 5, Page 421-434, May 2025.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

Glia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla, Carmen Nanclares, Sara Expósito, Grace Gall, Paulo Kofuji, Alfonso Araque, Eduardo D. Martín, Rosario Moratalla   +7 more
wiley   +1 more source

The Vacuolar Inositol Transporter BvINT1;1 Contributes to Raffinose Biosynthesis and Reactive Oxygen Species Scavenging During Cold Stress in Sugar Beet

Plant, Cell &Environment, Volume 48, Issue 5, Page 3471-3486, May 2025.
ABSTRACT Despite a high sucrose accumulation in its taproot vacuoles, sugar beet (Beta vulgaris subsp. vulgaris) is sensitive to freezing. Earlier, a taproot‐specific accumulation of raffinose was shown to have beneficial effects on the freezing tolerance of the plant.
Johannes Berg, Cristina Martins Rodrigues, Claire Scheid, Yana Pirrotte, Cristiana Picco, Joachim Scholz‐Starke, Wolfgang Zierer, Olaf Czarnecki, Dieter Hackenberg, Frank Ludewig, Wolfgang Koch, H. Ekkehard Neuhaus, Christina Müdsam, Benjamin Pommerrenig, Isabel Keller   +14 more
wiley   +1 more source