Results 31 to 40 of about 487,264 (268)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Research progress on symptom management in patients with prostate cancer

open access: yesHuli yanjiu, 2017
It reviewed the related research at home and abroad and expounded the characteristics,evaluation tools,influencing factors and intervention study of symptom burden in patients with prostate cancer.On this basis,it put forward some thoughts on the study ...
段晓磊   +4 more
doaj  

Palliative Sedation in COVID-19 End-of-Life Care. Retrospective Cohort Study

open access: yesMedicina, 2021
Background and Objectives: Descriptions of end-of-life in COVID-19 are limited to small cross-sectional studies. We aimed to assess end-of-life care in inpatients with COVID-19 at Alicante General University Hospital (ALC) and compare differences ...
Jose-Manuel Ramos-Rincon   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Psychometric properties of the Brazilian version of the Difficulties in Emotion Regulation Scale (DERS)

open access: yesTrends in Psychiatry and Psychotherapy, 2018
Introduction: Emotion regulation can be defined as the process by which individuals manage their emotional experience. It has been demonstrated that deficits in this ability are associated with various psychiatric disorders.
Ana Carolina Maciel Cancian   +4 more
doaj   +1 more source

Hispanic Populations, Veterans, and Symptom Assessment [PDF]

open access: yesJournal of Dual Diagnosis, 2017
The current issue of Journal of Dual Diagnosis covers a wide range of topics. Two of the papers focus on veterans.
E Sherwood, Brown, Alan I, Green
openaire   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Speech in the foreign accent syndrome: differential diagnosis between organic and functional cases

open access: yesDementia & Neuropsychologia, 2020
. Foreign accent syndrome (FAS) is an extremely rare disorder, with 112 cases described until 2019. We compare two cases of the foreign accent syndrome in native speakers of Brazilian Portuguese in its classic form (FAS) and psychiatric variant (FALS ...
Simone dos Santos Barreto   +1 more
doaj   +1 more source

Evaluation of Mortality and Morbidity According to Initial Symptoms in COVID-19 Patients Using Clinical Epidemiologic Data from the Korea Centers for Disease Control & Prevention

open access: yesMedicina, 2021
Background and Objectives: This study aimed to investigate whether initial symptoms of COVID-19 are associated with mortality and morbidity. Materials and Methods: The data of 5628 laboratory-confirmed COVID-19 patients were collected by the Korea ...
So Young Kim   +4 more
doaj   +1 more source

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