Results 321 to 330 of about 531,184 (380)

Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem. [PDF]

Elife
Khodadadi Z, Trpevski D, Lindroos R, Hellgren Kotaleski J.   +3 more
europepmc   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Preoperative Estimation of Deep Inferior Epigastric Perforator Flap Weight Using Synapse Vincent 3-dimensional Analysis: A Feasibility Study. [PDF]

Plast Reconstr Surg Glob Open
Akamine N, Matsumine H, Sakurai H.
europepmc   +1 more source

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Small cell lung cancer induces synaptic scaling to alter neuronal excitability. [PDF]

Commun Biol
Houcek AJ, Uzay B, Ildefonso GV, Omokehinde T, Monteggia LM, Quaranta V, Linkous A, Kavalali ET.   +7 more
europepmc   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science, EarlyView.
Single‐nucleus RNA sequencing of mid‐gestation brains from fetuses with nonsyndromic cleft lip and palate reveals major disruptions in cell composition, cell‐to‐cell signaling, and gene regulation. The transcription factor MEF2C is identified as a central regulator of these changes and shows that lowering MEF2C impairs synapse formation, linking cleft ...
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
wiley   +1 more source

Playing Multiple Parts: Unique Enzymatic and Structural Roles Orchestrated by SYNGAP1. [PDF]

Epilepsy Curr
Buchanan GF.
europepmc   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Afferent input differentially regulates establishment and maintenance of synapses in the mammalian retina. [PDF]

Sci Rep
Wallin J, Miller A, Sinha R, Hoon M.
europepmc   +1 more source

Comparative Single-Cell Transcriptome Analysis of c-Met Receptor Expressing and Non-Expressing Projection Neurons in the Developing Frontal and Visual Cortices. [PDF]

Dev Neurosci
Ali Marandi Ghoddousi R, Levitt P, Rady Z, Eagleson KL.   +3 more
europepmc   +1 more source