Results 131 to 140 of about 460,902 (390)

Bi‐Functional Topospecific Nanoparticles to Promote Immune‐Tumor Cell Engagement as A New Immunotherapeutic Strategy

open access: yesAdvanced Materials, EarlyView.
A Janus‐engineered nanoplatform (J‐pHLIP‐PD1), featuring separate tumor‐ and immune‐targeting faces, bridges melanoma cells and cytotoxic T lymphocytes using toposelective pHLIP and anti‐PD‐1 presentation. This strategy elicits robust antitumor responses, promotes immunogenic tumor cell death, suppresses lung metastasis in vivo, and provides a modular,
Alba Ortuño‐Bernal   +9 more
wiley   +1 more source

Abnormal Morphology and Synaptogenic Signaling in Astrocytes Following Prenatal Opioid Exposure

open access: yesCells
In recent decades, there has been a dramatic rise in the rates of children being born after in utero exposure to drugs of abuse, particularly opioids. Opioids have been shown to have detrimental effects on neurons and glia in the central nervous system ...
Ethan B. Niebergall   +7 more
doaj   +1 more source

Neurons Communication in the Hippocampus of Field CA3 of the White Rat Brain after Acute ischemia

open access: yesОбщая реаниматология, 2018
The aim of this study was to compare the pyramidal neurons, their processes and synapses in the stratum lucidum, stratum radiatum and stratum lacunosum of the molecular layer of the field CA3 of the hippocampus of the brain of white rats in the normal ...
A. S. Stepanov   +4 more
doaj   +1 more source

Challenges and Opportunities of Upconversion Nanoparticles for Emerging NIR Optoelectronic Devices

open access: yesAdvanced Materials, EarlyView.
The special photo‐responsiveness of upconversion nanoparticles has opened up a new path for the advancement of near‐infrared (NIR)‐responsive optoelectronics. However, challenges such as low energy‐conversion efficiency and high nonradiative losses still persist.
Sunyingyue Geng   +7 more
wiley   +1 more source

Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum

open access: yesFrontiers in Molecular Neuroscience, 2018
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression.
Fernando J. Sialana   +9 more
doaj   +1 more source

Recent Advances in Memristive Materials for Artificial Synapses

open access: yes, 2018
Neuromorphic architectures are in the spotlight as promising candidates for substituting current computing systems owing to their high operation speed, scale‐down ability, and, especially, low energy consumption.
Sun Gil Kim   +4 more
semanticscholar   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

open access: yesAdvanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi   +4 more
wiley   +1 more source

Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage

open access: yesBiology, 2015
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neurons.
Ewan West   +3 more
doaj   +1 more source

Neurexins: molecular codes for shaping neuronal synapses

open access: yesNature Reviews Neuroscience, 2021
A. Gomez   +2 more
semanticscholar   +1 more source

Neuromorphic Light‐Responsive Organic Matter for in Materia Reservoir Computing

open access: yesAdvanced Materials, EarlyView.
In this work we show that light‐responsive adaptive organic matter can store and process information at the matter level, and emulate neuromorphic functionalities such as short term memory, long term memory and visual memory. Besides demonstrating that material dynamics can be exploited for spatio‐temporal event detection and motion perception, we show
Federico Ferrarese Lupi   +5 more
wiley   +1 more source

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