Results 151 to 160 of about 187,009 (324)

Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

open access: yesAdvanced Science, EarlyView.
Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou   +9 more
wiley   +1 more source

A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel

open access: yesAdvanced Science, EarlyView.
An injectable conductive polymer hydrogel from poly (3,4‐ethylenedioxythiophene) (PEDOT) is developed to facilitate the recovery of electrophysiological function in injured optic nerve. The hydrogel can be injected directly at the injury site and spontaneously gel in place.
Changchun Yu   +12 more
wiley   +1 more source

Gate‐Tunable Dual‐Mode Optoelectronic Device for Self‐Powered Photodetector and Optoelectronic Synapse

open access: yesAdvanced Science, EarlyView.
A gate‐tunable MoTe₂/MoS₂ heterostructure‐based dual‐mode optoelectronic device functions as both a self‐powered photodetector and an optoelectronic synapse. It leverages the photovoltaic effect for photodetection and trapping states for synaptic behavior. Gate modulation enables seamless switching, paving the way for integrating neuromorphic computing
Yi Ouyang   +5 more
wiley   +1 more source

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

open access: yesAdvanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao   +9 more
wiley   +1 more source

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

open access: yesAdvanced Science, EarlyView.
Network‐based risk stratification of people living with HIV (PWH) on prolonged therapy using multi‐omics data identifies 44% of the patients are at risk of immunometabolic complications. A senescence‐associated myeloid cell‐driven plasma microenvironment drives immunometabolic dysregulation in at‐risk PWH.
Flora Mikaeloff   +32 more
wiley   +1 more source

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