Results 151 to 160 of about 1,092,184 (348)

Dopamine release regulation by astrocytes during cerebral ischemia

Neurobiology of Disease, 2013
Brain ischemia triggers excessive release of neurotransmitters that mediate neuronal damage following ischemic injury. The striatum is one of the areas most sensitive to ischemia.
Idaira Oliva, Miriam Fernández, Eduardo D. Martín   +2 more
doaj   +1 more source

Postnatal development of intrinsic and synaptic properties transforms signaling in the Layer 5 excitatory neural network of the visual cortex [PDF]

, 2011
Information flow in neocortical circuits is regulated by two key parameters: intrinsic neuronal properties and the short-term activity-dependent plasticity of synaptic transmission.
Etherington, Sarah J., S. J. Etherington, S. R. Williams, Etherington, S.J., Williams, S.R., Williams, Stephen R.   +5 more
core   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7

The Scientific World Journal, 2002
Eight subtypes of metabotropic glutamate (mGlu) receptors have been identified of which two, mGlu5 and mGlu7, are highly expressed at synapses made between CA3 and CA1 pyramidal neurons in the hippocampus.
Trevor J. Bushell, Gilles Sansig, Valerie J. Collett, Herman van der Putten, Graham L. Collingridge   +4 more
doaj   +1 more source

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95 [PDF]

, 2010
Although muscarinic acetylcholine receptors (mAChRs) and NMDA receptors (NMDARs) are important for synaptic plasticity, learning and memory, the manner in which they interact is poorly understood. We found that stimulation of muscarinic receptors, either
Jihoon Jo, Daniel J Whitcomb, Sheng, Morgan, Futai, Kensuke, Amici, Mascia, Dickinson, BA, Sheng, M., Winters, Bryony Laura, Lee, Youn-Bok, Cho, K, Dickinson, Bryony, Lee, Younbok; id_orcid, Futai, K., Cho, Kwangwook, Jo, J, Son, Gi Hoon, Bryony A Dickinson, Whitcomb, D, Youn-Bok Lee, Graham L Collingridge, Winters, BL, Kim, M.J., Myung Jong Kim, Kim, Myung Jong, Collingridge, GL, Collingridge, Graham L, Amici, M, Winters, Bryony L, Son, GH, Dickinson, Bryony A, Mascia Amici, Whitcomb, Daniel J, Kim, Myungjong, Gi Hoon Son, Bryony L Winters, Kwangwook Cho, Kensuke Futai, Morgan Sheng, Lee, YB, Jo, Jihoon, Whitcomb, Daniel   +40 more
core   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Maturation of PNN and ErbB4 Signaling in Area CA2 during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory

Cell Reports, 2019
Summary: Adolescence is a vulnerable period characterized by major cognitive changes. The mechanisms underlying the emergence of new cognitive functions are poorly understood.
Soledad Domínguez, Christophe Clément Rey, Ludivine Therreau, Aurélien Fanton, Dominique Massotte, Laure Verret, Rebecca Ann Piskorowski, Vivien Chevaleyre   +7 more
doaj   +1 more source

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

Nature Communications, 2017
High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly understood.
M. Spinelli, S. Fusco, M. Mainardi, F. Scala, F. Natale, Rosita Lapenta, A. Mattera, M. Rinaudo, D. D. Li Puma, C. Ripoli, A. Grassi, M. D'Ascenzo, C. Grassi   +12 more
semanticscholar   +1 more source

Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing

Advanced Materials, EarlyView.
This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long, Huanyu Zhou, Jaewan Ko, Hongwei Tan, Jaemin Lim, Yanfei Zhao, Daehan Kang, Eojin Yoon, Gyeong‐Tak Go, Somin Kim, Seung‐Woo Lee, Chan‐Yul Park, Hyojun Choi, Hyeran Kim, Hyung Joong Yun, Sung Hyuk Park, Kwan Sik Park, Jeong Woo Park, Mungeun Kim, Yong Soo Cho, Ho Won Jang, Wenqiang Yang, Min Hyuk Park, Wan Ki Bae, Sebastiaan van Dijken, Joona Bang, Tae‐Woo Lee   +26 more
wiley   +1 more source

Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis

Frontiers in Neurology, 2019
Introduction: Disease course of multiple sclerosis (MS) is negatively influenced by proinflammatory molecules released by activated T and B lymphocytes and local immune cells.
Mario Stampanoni Bassi, Antonietta Gentile, Ennio Iezzi, Sara Zagaglia, Alessandra Musella, Ilaria Simonelli, Luana Gilio, Roberto Furlan, Annamaria Finardi, Girolama A. Marfia, Livia Guadalupi, Silvia Bullitta, Georgia Mandolesi, Diego Centonze, Diego Centonze, Fabio Buttari   +15 more
doaj   +1 more source