Results 31 to 40 of about 1,268 (267)

The Distribution of the Perfect Auxiliaries be/have in Middle English Texts [PDF]

Anglica. An International Journal of English Studies, 2018
Like many Germanic languages, English has developed specific periphrastic constructions to express perfective meaning. Before being fully grammaticalized in the 16th century, they were used occasionally in Old and Middle English as complex verb phrases
Katarzyna Alicja Zdziera
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Continental synchronicity of human influenza virus epidemics despite climactic variation [PDF]

PLOS Pathogens, 2018
The factors that determine the pattern and rate of spread of influenza virus at a continental-scale are uncertain. Although recent work suggests that influenza epidemics in the United States exhibit a strong geographical correlation, the spatiotemporal dynamics of influenza in Australia, a country and continent of approximately similar size and climate
Jemma L. Geoghegan, Aldo F. Saavedra, Sebastián Duchêne, Sheena Sullivan, Ian Barr, Edward C. Holmes   +5 more
openaire   +5 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Cognate objects of weather verbs in African languages of South Africa –from synchronic variation to a grammaticalization path

Stellenbosch Papers in Linguistics, 2017
The authors argue that the synchronic variation of cognate objects of weather verbs exhibited in six African languages of South Africa (Sepedi, Sesotho, Tshivenda, isiXhosa, Xitsonga, and isiZulu) has a diachronic explanation, and may be represented as a
Andrason, Alexander, Visser, Marianna W.
doaj   +1 more source

Parallel corpora. A real-time approach to the study of language change in progress [PDF]

Diacronia, 2015
The paper draws data from four matching one-million word corpora, namely Brown (US, 1961), LOB (GB, 1961), Frown (US, 1992) and FLOB (GB, 1991), in order to provide an integrated description of synchronic (regional and stylistic) variation and short-term
Christian Mair
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Regional varieties and diachronic changes in Chinese political discourse

Humanities & Social Sciences Communications, 2022
The present paper explores the synchronic variations and diachronic changes in political discourses in Hong Kong (HK) and in Mainland of People’s Republic of China (PRC).
Renkui Hou, Chu-Ren Huang, Kathleen Ahrens   +2 more
doaj   +1 more source