Results 221 to 230 of about 9,115 (324)

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

open access: yesAdvanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su   +18 more
wiley   +1 more source

Hierarchical Temporal Processing in the Primate Thalamocortical System: Insights from Nonlinguistic Structured Stimuli. [PDF]

open access: yesResearch (Wash D C)
Ye H   +17 more
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

open access: yesAdvanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling   +17 more
wiley   +1 more source

Optimizing microchannel heat sinks with rhomboid vortex generators: An artificial neural network approach and its application in superconducting synchronous condensers

open access: gold
Jiacheng Zhang   +7 more
openalex   +1 more source

Electromagnetic behaviour of the 30 MVA superconducting synchronous condenser.

open access: diamond, 1987
Masatami Iwamoto   +7 more
openalex   +2 more sources

Non‐Equilibrium Synthesis Methods to Create Metastable and High‐Entropy Nanomaterials

open access: yesAdvanced Science, EarlyView.
ABSTRACT Stabilizing multiple elements within a single phase enables the creation of advanced materials with exceptional properties arising from their complex composition. However, under equilibrium conditions, the Hume–Rothery rules impose strict limitations on solid‐state miscibility, restricting combinations of elements with mismatched crystal ...
Shuo Liu   +3 more
wiley   +1 more source

Emerging of Anomalous Higher‐Order Topological Phases in Altermagnet/Topological Insulator Heterostructure by Floquet Engineering

open access: yesAdvanced Science, EarlyView.
We combine altermagnet with topological insulators and subject the structure to Floquet driving. This breaks time‐reversal symmetry and creates a new type of higher‐order topological insulator. Its key feature is the emergence of programmable “0/π‐corner modes” that can be controlled by magnetic field direction, offering a novel dynamic platform for ...
Donghao Wang   +4 more
wiley   +1 more source

Breaking the Thick Electrode Paradox With an in situ VS2@V2CTx MXene Heterostructure for High‐Areal‐Capacity Batteries

open access: yesAdvanced Science, EarlyView.
This work pioneers an in situ gas‐phase conversion strategy to construct VS2@V2Tx heterostructures within a MWCNT network. The integrated architecture establishes interpenetrating electron/ion highways, enabling an ultra‐thick electrode (300 µm) to achieve a high areal capacity of 13.6 mAh cm−2 with exceptional cycling stability, demonstrating great ...
Lirong Wang   +9 more
wiley   +1 more source

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