Results 181 to 190 of about 231,367 (247)

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Dynamic cholinergic signaling differentially desynchronizes cortical microcircuits dependent on modulation rate and network connectivity. [PDF]

PLoS Comput Biol
Pandian S, Rich S.
europepmc   +1 more source

Pulmonary arterial mechanoreceptors modulate exercise‐induced sympathetic activation in healthy humans during moderate‐intensity hypoxic exercise

The Journal of Physiology, EarlyView.
Abstract figure legend This randomized cross‐over trial (N = 12) addressed the hypothesis that selective reduction of pulmonary arterial pressure (i.e. manipulation of pulmonary arterial mechanoreceptor activation) during hypoxic exercise would reduce sympathetic outflow (muscle sympathetic nerve activity (MSNA)) in healthy humans.
Michiel T. Ewalts, Thomas D. Griffiths, Andrew J. M. Douglas, Elliott J. Jenkins, Guto Wyn Hughes, Craig D. Steinback, Lydia L. Simpson, Samuel J. Oliver, Mike Stembridge, Jonathan P. Moore   +9 more
wiley   +1 more source

KCNJ4 variants disrupt inward-rectifier potassium channel function and cause refractory epilepsy. [PDF]

Epilepsia
Pan H, Liu D, Xu W, Li Y, Hu J, Henry O, Fuchs A, Jamra RA, Liu Z, He M, Chen Y, Wu S, Dong X, Chen Y, Wang P, Gu W, Jing H, Tang Y, Wang YJ, Mao X, Xiao N.   +20 more
europepmc   +1 more source

Effects of nocturnal periodic breathing on sympathetic nerve activity and ventilatory control at high altitude: a randomised, crossover study

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the randomised crossover study investigating the effects of nocturnal periodic breathing (nPB) on sympathetic activity and ventilatory acclimatisation in hypobaric hypoxia equivalent to 4000 m altitude. Participants completed two 3‐day sojourns where nPB was inhibited by increasing inspiratory CO2 fraction ...
Johanna Roche, James P. Fisher, Peter Rasmussen, Abubaker Ibrahim, Philip N. Ainslie, Rachel Turner, Giovanni Vinetti, Matteo Cesari, Michael Furian, Ambra Stefani, Nikolaus Netzer, Hannes Gatterer, Birgit Högl, Christoph Siebenmann   +13 more
wiley   +1 more source

Photovoltaic-Related "Black Swan" Hypothesis for Electric Power System: Phenomenology, Simulations, Experiences, and Prevention. [PDF]

Sensors (Basel)
Sladic S, Zivic E.
europepmc   +1 more source

Computational model of haemodynamics during atrial fibrillation

The Journal of Physiology, EarlyView.
Abstract figure legend We developed a simplified computational model that replicates patient‐specific haemodynamics during both normal sinus rhythm and atrial fibrillation (AF). Our computational model comprises: (1) an electrical subsystem that generates unco‐ordinated atrial and irregular ventricular activation times characteristic of AF and (2) a ...
Felix Plappert, Pim J.A. Oomen, Clara E. Jones, Emmanouil Charitakis, Lars O. Karlsson, Pyotr G. Platonov, Mikael Wallman, Frida Sandberg   +7 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Individual Differences in Heartbeat-Tone Synchronicity Judgments Suggest the Two-Alternative Heartbeat Detection Task Is a Poor Test of Cardiac Interoceptive Accuracy and Insight. [PDF]

Psychophysiology
Adams KL, Palmer R, Bird JM, Plans D, Cunningham A, Morelli D, Piercy T, Spooner R, Clemente R, Izagirre NI, Fueyo EF, Watling D, Brewer R, Budworth G, Cocirla D, Leganes-Fonteneau M, Todd J, Aspell JE, Bird G, Murphy J.   +19 more
europepmc   +1 more source

Intercalated disk structure, tissue heterogeneity and ion channel distribution modulate conduction and local calcium influx

The Journal of Physiology, EarlyView.
Abstract figure legend A, three‐dimensional representation of cardiac intercalated disk, reduced to a 100‐partition, computationally efficient network representation. B, ion dynamics within intercalated disk extracellular cleft space. C, rapid pacing leads to localized conduction block in tissue with regions of perturbed intercalated disk (ID ...
Nicolae Moise, Heather L. Struckman, James W. Smyth, Gregory S. Hoeker, Steven Poelzing, Rengasayee Veeraraghavan, Seth H. Weinberg   +6 more
wiley   +1 more source