Results 81 to 90 of about 117,920 (299)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Molecular and Genetic Basis of Non-Syndromic Tooth Agenesis
, 2015 Background: Tooth agenesis represents the most common anomaly of dental development, which according to Online Mendelian Inheritance in Man (OMIM) database, affects approximately 20% of the population.
A. Ševecová +3 more
core +1 more source
Methods for calculating syndromic indicator rates for syndromic systems.
, 2020 Methods for calculating syndromic indicator rates for syndromic systems.
Andre Charlett (125456) +7 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Preferred Workflows for Syndromic Surveillance Systems [PDF]
, 2009 Workflows are a sequence of information processing operations that people carry out to meet certain in-formational goals [1]. Using various user-centered design (UCD) techniques we uncovered the workflows that epidemiologists wished to follow when using ...
Guthrie, Glenn +2 more
core
Genetics and Molecular Biology, 2006 Deafness is a complex disorder affecting 1/1000 infants. In developed countries, more than 50% of deafness cases are thought to have a genetic cause. At least 40 loci for dominant non-syndromic deafness and another 30 for recessive non-syndromic deafness
Raquel Rabionet +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Evaluating syndromic surveillance systems [PDF]
, 2016 Syndromic surveillance systems are commonly presented in the literature but few are rigorously evaluated. We present and test an evaluation framework to examine which events can and cannot be detected, the time to detection and the efficacy of different ...
Elliot, Alex J. +8 more
core +1 more source
Diagnostic implications of associated defects in patients with typical orofacial clefts
Jornal de Pediatria, 2015 OBJECTIVES: To describe prevalence of associated defects and clinical-genetic characteristics of patients with typical orofacial clefts seen at a reference genetic service. METHODS: Descriptive study conducted between September of 2009 and July of 2014.
Isabella L. Monlleó +6 more
doaj +3 more sources