Results 51 to 60 of about 116,328 (245)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Climate change adaptation and mitigation in agriculture: a review of the evidence for synergies and tradeoffs

Environmental Research Letters
Agricultural practices that both support climate change mitigation and facilitate adaptation to a changing climate are critical for reducing greenhouse gas emissions while ensuring food security.
Lindsay Barbieri, Carolyn Bittner, Eva Wollenberg, E Carol Adair   +3 more
doaj   +1 more source

FROM SYSTEMIC LINGUISTICS TO SYNTHESIS WITH OTHER FIELDS OF KNOWLEDGE

RUDN Journal of Language Studies, Semiotics and Semantics, 2019
The article shows that G.P. Melnikov’s scientific heritage is still of great importance in the 21th century. As a prominent thinker of the 20th century he both deepened the concept of the systematic nature of the language by creating an evolutionary ...
Valentina A Maslova, Anton A Lavitski
doaj   +1 more source

Exploring Additive, Synergistic or Antagonistic Effects of Natural Plant Extracts on In Vitro Beef Feedlot-Type Rumen Microbial Fermentation Conditions

Animals, 2020
Six Essential oils (EO) (tea tree oil—TeTr, oregano oil—Ore, clove bud oil—Clo, thyme oil—Thy, rosemary oil—Ros, and sage oil—Sag) in Experiment 1; and different combinations of selected oils in Experiment 2, were ...
Ignacio Fandiño, Gonzalo Fernandez-Turren, Alfred Ferret, Diego Moya, Lorena Castillejos, Sergio Calsamiglia   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Bodywork as systemic and inter-enactive competence: Participatory process management in Feldenkrais Method® & Zen Shiatsu

Frontiers in Psychology, 2015
Our micro-ethnographic study demonstrates how bodywork skills in Feldenkrais and Shiatsu are infused with systemic sensitivities. A micro-genetic study both of process vignettes and bodyworkers’ subjective theories reveals their intrinsically systemic ...
Michael eKimmel, Christine eIrran, Martin Alois Luger   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Future of Social Europe and of European Integration at a Crossroads: How Can We Recover and Enforce Solidarity as a Fundamental Principle of European Constitutional Law (or Die)?

European Papers, 2019
(Series Information) European Papers - A Journal on Law and Integration, 2019 4(1), 257-268 | Dialogue | (Table of Contents) I. A reference point in the crucial debate about social Europe. - II.
Pietro Masala, Fernando Valdés Dal-Ré
doaj   +1 more source

THE IDEA OF SELF-ORGANIZATION IN THE SYSTEM OF PUBLIC ADMINISTRATION

RUDN Journal of Law, 2020
This article is devoted to the problem of theory and practice of public administration in modern conditions. Actualization is carried out by searching for a new paradigm approach in order to determine the starting points regarding optimization and ...
Aleksey V. Zyrianov
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source