Results 101 to 110 of about 649,001 (290)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Elucidating nuclear reprogramming mechanisms: taking a synergistic approach

Reproductive BioMedicine Online, 2008
Nuclear reprogramming is the process by which a differentiated somatic nucleus has developmental potential restored to it. It involves heritable changes in gene expression as well as structural and functional changes to chromatin structure. This process is naturally induced immediately after fertilization, but can also be artificially induced by ...
Stephen, Sullivan, Justin K, Ichida, Akihiro, Umezawa, Hidenori, Akutsu   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Molecular evidence for the association of a strain of Uganda variant of East African cassava mosaic virus to symptom severity in cassava (Manihot esculenta Crantz) fields in Togo [PDF]

, 2009
: Problem statement: This study was carried out to demonstrate that the severity of Cassava Mosaic Disease (CMD) in Togo, is not only influenced by synergism between cassava Begomoviruses in presence, but essentially by recombination between the ...
Adjata, K.D., Gumedzoe, M.Y.D., Muller, Emmanuelle, Peterschmitt, Michel, Traoré, Oumar   +4 more
core  

Disentangled Representations via Synergy Minimization

, 2017
Scientists often seek simplified representations of complex systems to facilitate prediction and understanding. If the factors comprising a representation allow us to make accurate predictions about our system, but obscuring any subset of the factors ...
Brekelmans, Rob, Galstyan, Aram, Harutyunyan, Hrayr, Steeg, Greg Ver   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

General systems perspective on achieving continuous synergy in a project organisation [PDF]

, 2007
Studies of construction labour productivity have revealed that limited predictability and multi-agent social complexity make long-range planning of construction projects extremely inaccurate.
Radosavljevic, Milan
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Synergistic Approach for Evaluating Climate Model Output for Ecological Applications

Frontiers in Marine Science, 2017
Increasing concern about the impacts of climate change on ecosystems is prompting ecologists and ecosystem managers to seek reliable projections of physical drivers of change.
Rachel D. Cavanagh, Eugene J. Murphy, Thomas J. Bracegirdle, John Turner, Cheryl A. Knowland, Stuart P. Corney, Walker O. Smith, Claire M. Waluda, Nadine M. Johnston, Richard G. J. Bellerby, Richard G. J. Bellerby, Andrew J. Constable, Andrew J. Constable, Daniel P. Costa, Eileen E. Hofmann, Jennifer A. Jackson, Iain J. Staniland, Dieter Wolf-Gladrow, José C. Xavier, José C. Xavier   +19 more
doaj   +1 more source