Results 251 to 260 of about 604,960 (300)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Synergistic Impacts of Arsenic and Antimony Co-contamination on Diazotrophic Communities

Microbial Ecology, 2021
Nitrogen (N) shortage poses a great challenge to the implementation of in situ bioremediation practices in mining-contaminated sites. Diazotrophs can fix atmospheric N2 into a bioavailable form to plants and microorganisms inhabiting adverse habitats.
Yongbin Li   +10 more
openaire   +2 more sources

Sarcopenia and Systemic Inflammation Synergistically Impact Survival in Oral Cavity Cancer

The Laryngoscope, 2020
ObjectivesSarcopenia and systemic inflammation can affect survival of advanced‐stage oral squamous cell carcinoma (OSCC) patients; however, their reciprocal associations with survival outcomes are yet to be investigated.Study DesignRetrospective review at a tertiary cancer center.MethodsPatients with stage III‐IVB OSCC that underwent surgery and (chemo)
Jie Lee   +8 more
openaire   +2 more sources

Alterations in Synergistic Muscle Activation Impact Fluctuations in Net Force

Medicine & Science in Sports & Exercise, 2009
Net muscle force recorded during voluntary contractions with multiple agonist muscles is the summated result of individual muscle forces. The purpose of this article is to synthesize recent findings from several studies on the modulations of muscle activity and force fluctuations during steady voluntary contractions with multiple agonist muscles in ...
Minoru, Shinohara   +2 more
openaire   +2 more sources

Synergistic methane formation kinetics for hydrogen impact on carbon

The Journal of Chemical Physics, 1986
A physical/chemical model is presented for the reaction kinetics for methane formation from carbon, due to bombardment by energetic (∼100’s eV) H+ ions and thermal (∼1 eV) H0 atoms. While the model was developed for H+ and H0, it can be readily applied to nonhydrogenic energetic particles (ions or atoms, e.g., Ar+, He+, He) in combination with thermal (
A. A. Haasz, J. W. Davis
openaire   +1 more source

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