Results 151 to 160 of about 771,131 (233)

TPdsm: a method based on TabPFN for prediction of deleterious synonymous mutations. [PDF]

Bioinform Adv
Zeng B, Hu M, Cui Z, Zhou S, Dai W.
europepmc   +1 more source

Synonymous mutations and the molecular evolution of SARS-CoV-2 origins. [PDF]

Virus Evol, 2021
Wang H, Pipes L, Nielsen R.
europepmc   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Captive Breeding of the Chinese Alligator Reduces Inbreeding but Increases Genetic Load

Integrative Zoology, EarlyView.
Captive breeding of the Chinese alligator successfully reduced genomic inbreeding but increased the burden of deleterious mutations. Genomic analyses indicate that managing both genetic diversity and genetic load is essential for the long‐term conservation of this critically endangered species.
Yihang Fan, Tao Pan, Nicolas Dussex, Tianming Lan   +3 more
wiley   +1 more source

Synonymous mutations in essential genes infrequently produce fitness effects in human cell lines. [PDF]

Nucleic Acids Res
Rao Y, Sokirniy I, O'Brien E, Pritchard J.   +3 more
europepmc   +1 more source

Genomic Diversity of the Endangered Guinan Toad‐Headed Lizard and Its Conservation Implications

Integrative Zoology, EarlyView.
We produced HiFi long reads and assembled a high‐quality genome for the Guinan toad‐headed lizard—Phrynocephalus guinanensis—and present a comprehensive conservation genomics assessment. Our findings clearly show population structure, a reduced genetic diversity pattern, and a strong bottleneck in demographic history, reaffirming the endangered status ...
Ying Chen, Song Tan, Yiru Wang, Xia Qiu, Da Kang, Weizhao Yang   +5 more
wiley   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

The impact of non-neutral synonymous mutations when inferring selection on nonsynonymous mutations. [PDF]

Genetics
Martinez I Zurita A, Kyriazis CC, Lohmueller KE.   +2 more
europepmc   +1 more source

Large-scale analysis of SARS-CoV-2 synonymous mutations reveals the adaptation to the human codon usage during the virus evolution. [PDF]

Virus Evol, 2022
Ramazzotti D, Angaroni F, Maspero D, Mauri M, D'Aliberti D, Fontana D, Antoniotti M, Elli EM, Graudenzi A, Piazza R.   +9 more
europepmc   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source