Results 41 to 50 of about 117,442 (231)

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

A tissue kallikrein in the synovial fluid of patients with rheumatoid arthritis [PDF]

, 1989
Tissue kallikrein is an enzyme that forms the vasoactive peptide kallidin from an endogenous substrate L-kininogen. Tissue kallikrein has been identified in joint fluids and in inflammatory infiltrates within synovial membranes.
Bhoola, K. D., Selwyn, B. M., Dieppe, P. A., Figueroa, C. D., Swan, A., Fink, Edwin   +5 more
core   +1 more source

An Unconventional and Novel Therapeutic Technique of Anterior Indirect Decompression in a Case of C6–C7 Synovial Cyst Associated with Radiculopathy

Indian Spine Journal, 2019
Synovial cysts are infrequent findings in the spine and mostly located in the lumbar area. Even rarer is the occurrence of a synovial cyst in the cervical spine.
Bharat R Dave, Gayadhar Behera, Yash Shah, Ajay Krishnan   +3 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

High Rate of Return to Sport in Competitive Athletes Undergoing Periacetabular Osteotomy With Concomitant Hip Arthroscopy

Arthroscopy, EarlyView.
Purpose To report the return‐to‐sport rate of competitive athletes with hip dysplasia, in relation to their preoperative level of competition, who underwent hip arthroscopy with concomitant periacetabular osteotomy (HA + PAO). Methods Patients participating in competitive sports who underwent HA + PAO for the correction of hip dysplasia between January
Alfred Mansour, Nicole Lemaster, Jacob Jelmini, Philip Sheedy, Anota Adekunle, Alexis Aboulafia   +5 more
wiley   +1 more source

SYNOVIAL CYST IN THE PROJECTION OF TIBIAL TUNNEL AFTER ACL RECONSTRUCTION (CASE REPORT)

Travmatologiâ i Ortopediâ Rossii, 2017
ACL  tears  are the  most  widespread  lesions  among  isolated  trauma  of knee  ligaments  that  require  early  surgical treatment especially in young active patients.
V. B. Bogatov, R. S. Sadykov, I. R. Ponamarev   +2 more
doaj   +1 more source

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Sequential catalytic nanosystem of carbon dots and uricase integrated with polydopamine for therapy of gouty wound ulceration

BMEMat, EarlyView.
Sequential dual‐catalytic treatment of the gout wound ulceration process by CDs‐Uri@PDA. (a) Synthesis steps and morphology of CDs‐Uri@PDA. (b) Sequential treatment process and mechanism of CDs‐Uri@PDA for gout wound ulceration according to (i) uric acid reduction, (ii) antibacterial activity, and (iii) anti‐inflammatory effects.
Yonglan Yang, Yang Yang, Pengpeng Ma, Ruiqi Zhu, Xia Pan, Shaoling Zheng, Bo Chen, Yanli Jin, Youcong Gong, Jie Liu, Tianwang Li, Xu Chen   +11 more
wiley   +1 more source

Malignancy within a Tail Gut Cyst: A Case of Retrorectal Carcinoid Tumour [PDF]

, 2014
Purpose. Tailgut cysts with malignant transformation are rare entities. We discuss the diagnostic strategy and treatment of a malignancy within a tailgut cyst. Methods.
Abukar, AA, Steele, RJC, R. J. C. Steele, P. V. Patil, Abukar, A. A., A. A. Abukar, Patil, P. V., THAHA, MA, C. B. Lim, Lim, C. B., Ramsanahie, A., Carey, F, A. Ramsanahie, M. A. Thaha, Steele, R. J. C., Thaha, M. A., Ramsanahie, A, B. J. Parcell, F. Carey, Lim, CB, Patil, PV, Parcell, B. J.; id_orcid, Carey, F., Parcell, BJ   +23 more
core   +1 more source