Results 181 to 190 of about 135,885 (308)

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Extracellular Vesicles in the Synovial Joint: Is there a Role in the Pathophysiology of Osteoarthritis? [PDF]

Malays Orthop J, 2019
Esa A, Connolly KD, Williams R, Archer CW.   +3 more
europepmc   +1 more source

Adipose‐derived and bone marrow aspirate concentrate injections for osteoarthritis: A scoping review

PM&R, EarlyView.
Abstract Background Osteoarthritis is a leading cause of disability worldwide, and cell‐based treatments including adipose‐derived and bone marrow aspirate have been sought by the lay and medical community as treatment options. Objective To perform a scoping review of published literature on cell‐based injections allowed by the U.S.
Leonardo P. Oliveira, Aaron Lear, Joseph Elphingstone, Derek Stokes, Rachel Chamberlain, Timothy Tiu, David Price, Megan Agnew, Stephanie Kliethermes, Sarah Sund, Leslie A. Christensen, Shane Shapiro, Kenneth Mautner   +12 more
wiley   +1 more source

Tgfβ signaling stimulates glycolysis to promote the genesis of synovial joint interzone in developing mouse embryonic limbs. [PDF]

Sci Adv
Song C, Sawall JK, Ji X, Song F, Liao X, Peng R, Ren H, Koyama E, Pacifici M, Long F.   +9 more
europepmc   +1 more source

Mechanisms of synovial joint and articular cartilage development. [PDF]

Cell Mol Life Sci, 2019
Chijimatsu R, Saito T.
europepmc   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Prodrug Nanomedicine for Synovium Targeted Therapy of Inflammatory Arthritis: Insights from Animal Model and Human Synovial Joint Fluid. [PDF]

Adv Healthc Mater
Nosrati Z, Chen YA, Bergamo M, Rodríguez-Rodríguez C, Chan J, Shojania K, Kherani RB, Chin C, Kelsall JT, Dehghan N, Colwill AM, Collins D, Saatchi K, Häfeli UO.   +13 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

A single cell transcriptional atlas of early synovial joint development.

Development, 2020
Bian Q, Cheng YH, Wilson JP, Su EY, Kim DW, Wang H, Yoo S, Blackshaw S, Cahan P.   +8 more
europepmc   +1 more source

Rheumatic Disease: Protease-Activated Receptor-2 in Synovial Joint Pathobiology. [PDF]

Front Endocrinol (Lausanne), 2018
McCulloch K, McGrath S, Huesa C, Dunning L, Litherland G, Crilly A, Hultin L, Ferrell WR, Lockhart JC, Goodyear CS.   +9 more
europepmc   +1 more source