Results 221 to 230 of about 1,242,856 (294)

Component Analysis Based on UHPLC‐Q‐Exactive‐Orbitrap/MS and Immune Regulatory Activity Assessment by an LPS‐Stimulated Macrophages Model of Sacha Inchi Shell (Plukenetia volubilis Linneo) Extract

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The extract of SISE was characterized by LC‐MS, and 44 constituents were identified. Immune function evaluation confirmed that SISWE has a bidirectional immune regulation effect. Further mechanistic studies revealed that SISWE alleviates inflammatory response via suppressing NF‐KB and MAPK signaling pathways.
Min Wang, Yin‐hong Xiang, Hui Li, Qin‐yi Li, Fan Ou‐Yang, Mei Liu, Yao He, Jing Wen, Mei‐qin Huang, Hui‐feng Sun, Zhi‐Gang Wang, Ning Zhang, Jian‐xin Liu   +12 more
wiley   +1 more source

Anti‐Inflammatory Effects of Vicatia thibetica De Boiss. in Rheumatoid Arthritis and Associated Multi‐Pathway Modulation In Vivo

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Vicatia thibetica de Boiss. (VTDB) extracts and fractions were screened for anti‐rheumatoid arthritis activity via UHPLC‐MS, network pharmacology, and CIA rat models. VTDB‐nBuOH stood out, regulating PI3K/Akt, JAK2/STAT3, macrophage polarization, and gut microbiota to relieve joint inflammation, with proteomics verifying its multi‐pathway regulatory ...
Mo‐Zi‐Li Adu, Wei Jiang, Min Li, Bo‐Wei Xia, En Yuan, Yue‐Zhi Tan, Wu‐Xin Yang, Guo‐Yue Zhong, Qin‐Ge Ma, Rong‐Rui Wei   +9 more
wiley   +1 more source

Botanical, Phytochemistry, Pharmacology and Applications of Genus Heracleum: A Review

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
This manuscript presents a comprehensive review of plant species in the genus Heracleum, from botanical classification and distribution to medicinal uses, phytochemistry, pharmacology, and applications, aiming to provide references for further exploration of their therapeutic value and research development.
Nan Zhang, Yuan Li, Zhi‐Yuan Guo, Ye‐Zi Ma, Miao‐Miao Xu, Dong‐Dong Zhang   +5 more
wiley   +1 more source

Screening of Active Ingredients From Ficus tikoua Bur. Against Rheumatoid Arthritis and Their Enrichment Using a β‐Cyclodextrin‐Based Monolith

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A β‐CD‐based monolith was prepared and used as solid‐phase extraction adsorbent for on‐line enrichment of compounds from Ficus tikoua Bur. Various fractions with different molecular sizes and polarities were obtained and anti‐inflammatory activity evaluations were conducted. The active ingredient against rheumatoid arthritis was screened out by further
Dan Zhang, Qianru Jiang, Min Li, Hongyuan Yan, Haiyan Liu   +4 more
wiley   +1 more source

Mitochondrial Metabolic Reprogramming in Macrophages: A Key Driver of Rheumatoid Arthritis. [PDF]

J Inflamm Res
Zhao J, Pan F, Nie G, Zheng F, Wang L, Han C.   +5 more
europepmc   +1 more source

Posteromedial Knee Capsule Tear Without Concomitant Ligament Rupture or Meniscal Pathology in a Pediatric Athlete

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT The posterior knee capsule is a critical structure for tibiofemoral stability, limiting hyperextension, and posterior translation. Injuries to this structure are rare and typically occur alongside anterior cruciate ligament (ACL) or posterior cruciate ligament (PCL) tears.
Arianna Paa, Doyle Ford, Faris Jafri, Kareem Siada, Keith Sims, Micah Lissy   +5 more
wiley   +1 more source

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

Enrichment and Proteomic Profiling of Stromal-Associated Extracellular Vesicle Subpopulations From Arthritic Synovial Fluid by Size-Exclusion Chromatography Coupled to CD90-Directed Immunocapture. [PDF]

J Extracell Vesicles
Kurth S, Hanser E, Häner-Massimi S, Giaglis S, Geier F, Burri D, Buczak K, Heider U, Wild S, Acklin YP, Egloff C, Tiaden AN, Kyburz D.   +12 more
europepmc   +1 more source

Recalibrating the apoptotic threshold: Ubiquitin‐regulated ER stress signalling in colorectal cancer

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Ubiquitin‐dependent turnover of ER‐stress sensors, proteostasis factors, and apoptotic regulators can recalibrate the apoptotic threshold in colorectal cancer, balancing adaptive survival against terminal cell death. Defining these context‐dependent vulnerabilities may enable strategies that overcome stress adaptation and restore apoptotic competence ...
Jing Hu, Shanliang Zheng, Ying Hu
wiley   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source