Results 291 to 300 of about 91,327 (332)

Gene and RNA Editing: Revolutionary Approaches to Treating Diseases

MedComm, Volume 6, Issue 10, October 2025.
The image illustrates gene editing technologies: DNA editing using CRISPR–Cas9 and RNA editing via Cas13d, with their clinical applications and ethical risks. DNA editing allows precise gene modifications for conditions like amyotrophic lateral sclerosis [ALS] and Huntington's disease, while RNA editing supports multiplexed modifications.
Jia‐Mei Li, Jie Huang, Yan Liao, Ting Hu, Chang‐Li Wang, Wang‐Zheqi Zhang, Chen‐Wei Huang   +6 more
wiley   +1 more source

Role of Neutrophils in Homeostasis and Diseases

MedComm, Volume 6, Issue 10, October 2025.
Neutrophils are involved in the progression of various diseases through multiple mechanisms, including inflammatory responses, endothelial damage, and NETs release. (A) Cancer development and progression; (B) sepsis; (C) COVID‐19; (D) autoimmune diseases; (E) neurodegenerative diseases; (F) T2DM (e.g., diabetic foot ulcers (DFUs)); (G) nonalcoholic ...
Xingyu Chang, Yulin Liu, Junjun Qiu, Keqin Hua   +3 more
wiley   +1 more source

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions

MedComm, Volume 6, Issue 10, October 2025.
PROTACs are reshaping drug discovery through targeted protein degradation. Clinical programs now extend to prostate, breast, lung, hematologic, and solid tumors, with key targets including AR, ER, BTK, STAT3, Bcl‐xL, BRD9, Kras, and so on. These degraders overcome resistance, broaden therapeutic scope, and provide solutions for “undruggable” proteins ...
Gang Fan, Shilin Chen, Qingping Zhang, Na Yu, Ziyang Shen, Zhaoji Liu, Weiming Guo, Zhihan Tang, Jing Yang, Miao Liu   +9 more
wiley   +1 more source

Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications

MedComm, Volume 6, Issue 10, October 2025.
Schematic diagram illustrating the comprehensive landscape of hydrogel microspheres (HMs). (A) The components of HMs. (B) Preparation technologies employed in fabricating HMs. (C) The diverse applications of HMs across different fields. (D) The therapeutic applications of HMs in the treatment of various systemic diseases, demonstrating their potential ...
Meng Yang, Yuanyuan Shi, Feng Wang, Xin Zhang, Jiayi Shao, Fan Yang, Hao Sun, Chong Zhang, Zheng Zhou, Jianyong Huang, Pengyu Lv, Patrick Shu‐Hang Yung, Jin Cheng, Hong‐Jie Huang, Jian‐Quan Wang   +14 more
wiley   +1 more source

Cuproptosis Facilitates Chronic Skin Inflammation by Regulating the α‐Ketoglutarate/H3K4me3/Ferritin Heavy Chain 1 Signaling Pathway‐Mediated Ferroptosis

MedComm, Volume 6, Issue 10, October 2025.
Cuproptosis plays critical roles in psoriasis and atopic dermatitis (AD). SLC31A1‐mediated cuproptosis increases α‐ketoglutarate, activating KDM5B, which demethylates H3K4me3 domains in FTH1, lowering its transcription and promoting ferroptosis, thus advancing inflammatory skin diseases.
Pian Yu, Kaixuan Li, Shifu Luo, Rongxuan Yan, Xiaoqing Yi, Chi Fang, Sihui Ma, Guanming Wang, Fanyan Luo, Xiang Chen, Cong Peng, Jie Li   +11 more
wiley   +1 more source

Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway. [PDF]

J Cell Mol Med
Jie L, Liu J, Zhu Z, Huang Z, Liu Y, Liu G, Shen X, Li Y, Shi X.   +8 more
europepmc   +1 more source

The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases

Pharmacology Research &Perspectives, Volume 13, Issue 5, October 2025.
ABSTRACT Andrographolide, a diterpenoid component found in traditional Chinese medicine Andrographis paniculata, is known as a natural antibiotic and can be used to treat inflammatory lesions of various systemic diseases. In recent years, andrographolide derivatives have been continuously synthesized and have shown good anti‐inflammatory ...
Xiaoqin Shan, Siyi Li, Jiayi Liu, Can Wang, Yao Wei, Jiayi Shi, Xinyue Zhang, Lili Gu   +7 more
wiley   +1 more source