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The role of synovitis in osteoarthritis [PDF]

Therapeutic Advances in Musculoskeletal Disease, 2010
Osteoarthritis (OA) is the most common form of arthritis worldwide yet there is still a lack of effective treatments for this condition. Increasingly, attention has turned to the role of the synovium in OA as it is now recognized, in part from the use of modern imaging techniques, that synovitis is both common and associated with pain.
Claire Y J, Wenham, Philip G, Conaghan
openaire   +2 more sources

Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis

Mediators of Inflammation, 2014
Objective. To explore the correlation between matrix metalloproteinase- (MMP-) 3 and histological synovitis in rheumatoid arthritis (RA). Methods. Serum MMP-3 of 62 patients with active RA was detected by ELISA.
Jian-Da Ma, Jing-Jing Zhou, Dong-Hui Zheng, Le-Feng Chen, Ying-Qian Mo, Xiu-ning Wei, Li-Juan Yang, Lie Dai   +7 more
doaj   +1 more source

Monoarticular synovitis of knee: dealing with the dilemma

SICOT-J, 2020
Introduction: Chronic synovitis involving a single large joint remains a diagnostic dilemma. We present 61 cases of chronic synovitis of the knee, followed prospectively for 2 years.
Goyal Tarun, Paul Souvik, Kundu Choudhury Arghya, Kalonia Tushar   +3 more
doaj   +1 more source

Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokines/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis.

PLoS ONE, 2021
ObjectivesWe aimed to explore the associations of musculoskeletal inflammation patterns with peripheral blood innate lymphoid cell (ILC) populations, serum cytokines/chemokines, and treatment response to methotrexate in patients with rheumatoid arthritis
Manami Kato, Kei Ikeda, Takahiro Sugiyama, Shigeru Tanaka, Kazuma Iida, Kensuke Suga, Nozomi Nishimura, Norihiro Mimura, Tadamichi Kasuya, Takashi Kumagai, Hiroki Furuya, Taro Iwamoto, Arifumi Iwata, Shunsuke Furuta, Akira Suto, Kotaro Suzuki, Eiryo Kawakami, Hiroshi Nakajima   +17 more
doaj   +1 more source

Blood flow velocity in the anterior humeral circumflex artery and tear size can predict synovitis severity in patients with rotator cuff tears [PDF]

Clinics in Shoulder and Elbow
Background Rotator cuff tears are often associated with synovitis, but the ability of noninvasive ultrasonography to predict the severity of synovitis remains unclear.
Takahiro Machida, Takahiko Hirooka, Akihisa Watanabe, Hinako Katayama, Yuki Matsukubo   +4 more
doaj   +1 more source

Validity and diagnostic performance of fluorescence optical imaging measuring synovitis in hand osteoarthritis: baseline results from the Nor-Hand cohort

Arthritis Research & Therapy, 2020
Objective Fluorescence optical imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in persons with hand OA, comparing it ...
Øystein Maugesten, Alexander Mathiessen, Hilde Berner Hammer, Sigrid Valen Hestetun, Tore Kristian Kvien, Till Uhlig, Sarah Ohrndorf, Ida Kristin Haugen   +7 more
doaj   +1 more source

Synovitis in osteoarthritis: the current state of the problem

Современная ревматология, 2021
The article presents current data on synovitis (inflammation of the synovial membrane), which is often the only clinical manifestation of osteoarthritis (OA), and considered to be one of the risk factors for the OA development.
I. S. Dydykina, E. V. Arutyunova, P. S. Kovalenko, E. V. Nikolaeva, A. V. Naumov   +4 more
doaj   +1 more source

Arthroscopic assessment of stifle synovitis in dogs with cranial cruciate ligament rupture. [PDF]

PLoS ONE, 2014
Cranial cruciate ligament rupture (CR) is a degenerative condition in dogs that typically has a non-contact mechanism. Subsequent contralateral rupture often develops in dogs with unilateral CR.
Jeffrey P Little, Jason A Bleedorn, Brian J Sutherland, Ruth Sullivan, Vicki L Kalscheur, Megan A Ramaker, Susan L Schaefer, Zhengling Hao, Peter Muir   +8 more
doaj   +1 more source

Do Dynamic Plantar Pressures Differ Based on Sonographic Evidence of Metatarsophalangeal Joint Synovitis in People With Rheumatoid Arthritis?

ACR Open Rheumatology
Objective The metatarsophalangeal joints (MTPJs) are the most common location for synovitis in people with rheumatoid arthritis (RA), yet their association with plantar foot pressures has received very little attention.
Libby Anderson, Belinda Ihaka, Catherine Bowen, Charlotte Dando, Sarah Stewart   +4 more
doaj   +1 more source

Development and validation of cuproptosis-related genes in synovitis during osteoarthritis progress

Frontiers in Immunology, 2023
Osteoarthritis (OA) is one of the most common refractory degenerative joint diseases worldwide. Synovitis is believed to drive joint cartilage destruction during OA pathogenesis. Cuproptosis is a novel form of copper-induced cell death.
Bohan Chang, Zhehan Hu, Liang Chen, Zhuangzhuang Jin, Yue Yang   +4 more
doaj   +1 more source