Results 71 to 80 of about 43,166 (228)

Distinct late-stage osteoarthritis profiles identified through NF-κB, TNF-α, and TGF-β–driven synovial inflammation and pain

Scientific Reports
This study delineates distinct late-stage osteoarthritis (OA) profiles, characterized by NF-κB, TNF-α, and TGF-β–mediated synovial inflammation and pain, in a cohort of 31 patients undergoing joint arthroplasty.
Sofija Semenistaja, Liba Sokolovska, Simons Svirskis, Peteris Studers, Valerija Groma, Sandra Skuja   +5 more
doaj   +1 more source

Pigmented Villonodular Synovitis Causing Osteonecrosis of the Femoral Head: A Case Report

Case Reports in Orthopedics, 2013
We report a case of a 27-year-old man with pigmented villonodular synovitis of the hip joint with coincident osteonecrosis of the femoral head. According to our review of the English-language literature, no detailed report of osteonecrosis of the femoral
Tomohiro Mimura, Taku Kawasaki, Keitaro Yagi, Kanji Mori, Shinji Imai, Yoshitaka Matsusue   +5 more
doaj   +1 more source

Dosing Biologic Drugs for Patients With Obesity: One Size Does Not Fit All

Arthritis &Rheumatology, EarlyView.
Stephen J. Balevic, Daniel Gonzalez, Bernd Meibohm   +2 more
wiley   +1 more source

CD14 plays a critical role in pain and inflammation across multiple models of post‐traumatic osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine OA models that vary in severity of pathology and rate of progression, to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Leukaemic synovitis [PDF]

Rheumatology, 2006
P D, Ziakas, S, Giannouli, A G, Tzioufas, M, Voulgarelis   +3 more
openaire   +2 more sources

Tissue Damage in Rheumatoid Arthritis is Genetically linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, Accepted Article.
Objectives Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biological mechanism underlying this association. Methods Expression of surrounding genes was compared between rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E Mains, Betty A Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Immunophenotypic distinction between pigmented villonodular synovitis and haemosiderotic synovitis

Journal of Clinical Pathology, 2009
Aim: Haemosiderotic synovitis (HS) is caused by excessive bleeding into a joint. It occurs secondary to a variety of conditions and needs to be distinguished from pigmented villonodular synovitis (PVNS) for the purposes of treatment.
Mahendra, G, Kliskey, K, Athanasou, N
openaire   +2 more sources

Validation of International Classification of Diseases (ICD) code‐based case definitions of immune checkpoint inhibitor associated inflammatory arthritis from administrative health data

Arthritis &Rheumatology, Accepted Article.
Background Immune checkpoint inhibitors (ICIs) for cancer can lead to immune‐related adverse events, including ICI‐associated inflammatory arthritis (ICI‐IA). There are no validated International Classification of Diseases (ICD) code–based case definitions for ICI‐IA.
Manar Elsayed, Zoe Hsu, Finlay A. McAlister, William D. Leslie, Lisa M. Lix, Sasha Bernatsky, Suzanne N Morin, Michelle M Graham, Aurore Fifi‐Mah, Shahin Jamal, Janet Roberts, Carrie Ye   +11 more
wiley   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

A novel knee implant for total knee arthroplasty meets expectations at 10 years. First long‐term follow‐up report of clinical outcomes and survivorship

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Achieving a “forgotten knee” after total knee arthroplasty (TKA) remains a primary goal in modern knee replacement surgery. Anatomic implant designs aim to replicate native knee anatomy and kinematics, potentially improving patient satisfaction and functional outcomes.
Alice Montagna, Marina Marescalchi, Virginia Cinelli, Rudy Sangaletti, Luca Andriollo, Francesco Benazzo, Stefano Marco Paolo Rossi   +6 more
wiley   +1 more source