Results 51 to 60 of about 626,366 (290)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Prediction of microvascular obstruction by coronary artery angiography score after acute ST-segment elevation myocardial infarction: a single-center retrospective observational study

BMC Cardiovascular Disorders, 2022
Background Some coronary artery angiography (CAG) scores are associated with the no-reflow phenomenon after percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI).
Ziwen Li, Hongbin Yin, Dehua Wang, Yayun Zhang, Yongli Feng, Yi Zhou, Ying Zhou   +6 more
doaj   +1 more source

The Role of Artificial Intelligence in Medication Management for Older Adults: A Systematic Review

AGING MEDICINE, EarlyView.
Artificial intelligence enhances medication management for older adults by improving adherence, personalizing treatment, and predicting risks. Despite benefits, challenges remain in usability, trust, ethics, and system integration. Successful adoption requires user‐centered design, ethical safeguards, and seamless healthcare integration to ensure safe,
Dipak Chandra Das, Moustaq Karim Khan Rony, Shovit Dutta, MD. Sami Al Zubair Zujbe, Tapan Bhattacharjee, Niloy Debnath, Shabbir Abdullah Maruf, Chowdhury Galib Mortuza, Farhana Rahman, Akash Das   +9 more
wiley   +1 more source

The ModelCC Model-Driven Parser Generator

, 2015
Syntax-directed translation tools require the specification of a language by means of a formal grammar. This grammar must conform to the specific requirements of the parser generator to be used.
Berzal, Fernando, Cortijo, Francisco J., Cubero, Juan-Carlos, Quesada, Luis   +3 more
core   +2 more sources

The Necessity of Dynamic Workflow Managers for Advancing Self‐Driving Labs and Optimizers

Advanced Intelligent Discovery, EarlyView.
We assess the maturity and integration readiness of key methodologies for Materials Acceleration Platforms, highlighting the need for dynamic workflow managers. Demonstrating this, we integrate PerQueue into a color‐mixing robot, showing how flexible orchestration improves coordination and optimization.
Simon K. Steensen, Patrick W. V. Butler, Jesper R. Pedersen, Nis Fisker‐Bødker, Tejs Vegge, Jin Hyun Chang, Ivano E. Castelli   +6 more
wiley   +1 more source

Decoding spatial layout patterns of traditional houses in urban kampung settlements

Journal of Architecture and Urbanism
Understanding and identifying the spatial layout patterns of traditional houses is a pivotal feature for preserving and enhancing the cultural heritage of twelve houses which have been an object to be studied.
Nova Asriana, Rendy Perdana Khidmat
doaj   +1 more source

Large Language Model in Materials Science: Roles, Challenges, and Strategic Outlook

Advanced Intelligent Discovery, EarlyView.
Large language models (LLMs) are reshaping materials science. Acting as Oracle, Surrogate, Quant, and Arbiter, they now extract knowledge, predict properties, gauge risk, and steer decisions within a traceable loop. Overcoming data heterogeneity, hallucinations, and poor interpretability demands domain‐adapted models, cross‐modal data standards, and ...
Jinglan Zhang, Xinyi Chen, Xu Ye, Yulin Yang, Bin Ai   +4 more
wiley   +1 more source

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, EarlyView.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

Attention Modulates Electrophysiological Responses to Simultaneous Music and Language Syntax Processing

Brain Sciences, 2019
Music and language are hypothesized to engage the same neural resources, particularly at the level of syntax processing. Recent reports suggest that attention modulates the shared processing of music and language, but the time-course of the effects of ...
Daniel J. Lee, Harim Jung, Psyche Loui
doaj   +1 more source