Results 141 to 150 of about 16,144,289 (353)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
What is design? : an empirical investigation into conceptions of design in the community of design stakeholders [PDF]
This thesis describes a project investigating conceptions of design in the community of design stakeholders. A 'democratization of design' is identified, in terms of a widened mode of design engagement.
Micklethwaite, Paul Hilton
core
Mapping the landscape of circular design tools [PDF]
Circular design tools can help companies to move from linear to circular design practices and an increased uptake of such tools have potential to help realise the circular transition.
Selvefors, Anneli +3 more
core +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Post-industrial areas on the lens of systemic design towards flourishing urban resilience [PDF]
, 2018 Contemporary worldwide economy has evolved into a global multidimensional process that manifests itself in cities through radical changes in human population densities and urban fabric. Such transformations are so rapid that cities are lag behind to cope
Giraldo Nohra, Carolina +3 more
core
Fostering Creativity in School Makerspaces: Principles and a Framework for Assessing Creativity-Supportive Design [PDF]
School-based makerspaces are increasingly recognized as powerful contexts for fostering creativity, collaboration, and problem-solving. However, educational research on creativity has often prioritized individual traits or final products ...
Olafsson, Brynjar +3 more
core +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
IEEE Journal of MicrowavesThis paper introduces a rapid filter synthesis method that utilizes the improved Chebyshev function to design versatile broadband on-chip filters with multiple (N) independently controlled transmission zeros (TZs). It eliminates the constraints of narrow
Xiaolong Huang +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source