Results 171 to 180 of about 10,563,202 (308)

Hardware-aware knowledge-distilled CNN for real-time classification of plaque-associated angiographic findings on FPGA. [PDF]

Front Digit Health
Pravalika N, Afthab J, Rajamani V.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Academic Design

, 2015
This paper proposes to reshape the discussion design schools about the relationship of design practice to research. Many universities now have very successful design departments that educate high-level design practitioners.
Dorst, CH Kees, Koskinen, IK, Koskinen, Ilpo K., Dorst, CH, Dorst, C.H.   +4 more
core  

Beyond the golden rule of polymer network dynamics: Design principles for tissue-mimetic viscoelasticity. [PDF]

Sci Adv
Moses EA, Wang CJ, Collins J, Garcia J, Marshall JH, Dobrynin AV, Sheiko SS.   +6 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Design, Synthesis, <i>In Vitro</i> Biological Evaluation, and <i>In Silico</i> Analyses of Novel Pyrano[3,4‑<i>b</i>]indole-Containing Compounds as Promising Multitarget Candidates for Alzheimer's Disease and Cancer Therapy. [PDF]

ACS Omega
Comert Onder F, Onder A, Ural K, Sıkık M, Abusharkh KAN, Ozpolat B, Ay M.   +6 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Synthesis of Sb(iii)-immobilized on nitrogen-doped mesoporous silica nanotubes for efficient and green preparation of pyrazolopyranopyrimidines: comprehensive characterization, green chemistry evaluation and computational antifungal profiling against 5TZ1. [PDF]

RSC Adv
Jafari Taadi Z, Moradi L, Moazeni Bistgani A.   +2 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Quinoline-Based Scaffolds in Anticancer Drug Discovery: Molecular Targets, Synthetic Strategies, and Biological Advances. [PDF]

ChemMedChem
Raza A, Wadhwa P, Sharma S.
europepmc   +1 more source