Results 41 to 50 of about 16,144,289 (353)

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

Science, 2010
Let There Be Life The DNA sequence information from thousands of genomes is stored digitally as ones and zeros in computer memory. Now, Gibson et al. (p.
D. G. Gibson, J. Glass, C. Lartigue, V. Noskov, R. Chuang, Mikkel A. Algire, G. A. Benders, Michael G. Montague, Li Ma, Monzia M. Moodie, C. Merryman, S. Vashee, R. Krishnakumar, N. Assad-Garcia, C. Andrews-Pfannkoch, Evgeniya Denisova, L. Young, Z. Qi, Thomas H. Segall-Shapiro, C. Calvey, P. Parmar, C. Hutchison, Hamilton O. Smith, J. Venter   +23 more
semanticscholar   +1 more source

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

bioRxiv, 2020
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate.
Linlin Zhang, Daizong Lin, Y. Kusov, Yong Nian, Q. Ma, Jiang Wang, A. von Brunn, P. Leyssen, K. Lanko, J. Neyts, Adriaan H. de Wilde, E. Snijder, Hong Liu, R. Hilgenfeld   +13 more
semanticscholar   +1 more source

Newly Designed and Synthesized Curcumin Analogs with in vitro Cytotoxicity and Tubulin Polymerization Activity [PDF]

, 2014
Novel curcumin analogs with 4-piperidone ring were designed, synthesized, and evaluated for their cytotoxic activities against five different cancer cell lines.
Abouzid, and Khaled A. M., Gullbo, Joachim,, Youssef, Khairia M., Abouzid, Khaled A. M., Ismail, Nasser S. M., Fawzy, Iten M., Ismai, Nasser S. M., Gullbo, Joachim   +7 more
core   +1 more source

Design prototyping methods: state of the art in strategies, techniques, and guidelines [PDF]

, 2017
Prototyping is interwoven with nearly all product, service, and systems development efforts. A prototype is a pre-production representation of some aspect of a concept or final design.
Crawford, Richard, Bradley Camburn, David Anderson, Kevin Otto, Viswanathan, Vimal, Camburn, Bradley, Wood, Kristin, Julie Linsey, Otto, Kevin, Anderson, David, Vimal Viswanathan, Jensen, Daniel, Linsey, Julie, Daniel Jensen, Richard Crawford, Kristin Wood   +15 more
core   +2 more sources

Smart water network infrastructures

Journal of Water Reuse and Desalination, 2023
This paper presents a solution to convert the conventional water network into a smart water network (SWN). Scenarios are synthesized for water recycling inside buildings with less water consumed, minimizing the overall cost.
Hossam A. Gabbar, Sultan Islam, Ahmed Ramadan   +2 more
doaj   +1 more source

Course Design Thinking: Navigating Tensions at the Intersection of Design Thinking and Engineering Course Design [PDF]

, 2023
In recent years, several researchers and educators have explored how design thinking might be applied to education design practices. These explorations have ranged from general use toolkits to theoretical framings to empirical investigations. While these
Mina, Mani, Fila, Nicholas D, Jones III, Phillip H, Duwe, Henry, Rover, Diane T   +4 more
core   +1 more source

Research on Optimization Design Method of MIMO Radar Waveform Based on Frequency-Orthogonal LFM

IEEE Access
In the field of Multiple Input Multiple Output(MIMO) radar waveform design, how to design an orthogonal waveform with high performance is one of the current hot topics. The Orthogonal Frequency Division Multiplexing - Linear Frequency Modulation(OFDM-LFM)
Xinrong Mao, Baiyang Cai, Meng Xia, Lichao Yang   +3 more
doaj   +1 more source

Storage Device Sizing for a Hybrid Railway Traction System by Means of Bicausal Bond Graphs [PDF]

, 2006
In this paper, the application of bicausal bond graphs for system design in electrical engineering is emphasized. In particular, it is shown how this approach is very useful for model inversion and parameter dimensioning.
Sareni, Bruno, Gandanegara, Grace, Roboam, Xavier   +2 more
core   +1 more source

Kaolin Modified Nano Zero Valent Iron Synthesis via Box-Behnken Design Optimization

Applied Environmental Research, 2017
Nano zero valent iron (NZVI) has been extensively studied for its application to treat pollutants, particularly in contaminated water. This research studies enhancement of the reducing power of NZVI using kaolin as a supporter and ethanol as a medium ...
Pummarin Khamdahsag, Wannakan Thongkao, Apichart Saowapakpongchai, Visanu Tanboonchuy   +3 more
doaj   +7 more sources

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source