Results 181 to 190 of about 3,358,432 (297)

SYN-OCT:A synthetic dataset of ocular optical coherence tomography images from healthy and glaucoma eyes. [PDF]

Sci Data
Wong D, Sreejith Kumar AJ, Chong RS, Nongpiur ME, Husain R, Wong T, Perera S, Aung T, Tan B, Cheng CY, Vithana EN, Chua J, Cherecheanu AP, Schmetterer L.   +13 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

SynthCraft: An AI partner for synthetic data generation to support data access and augmentation in healthcare. [PDF]

PLOS Digit Health
Callender T, Boyd A, Davis R, Ruhrberg Estevez S, Lavista Ferres JM, van der Schaar M.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Total chemical synthesis of pentameric cholera toxin subunit B.

Chem Commun (Camb)
Spaltenstein P, Scherer SR, Jones TE, Giesler RJ, Kay MS.   +4 more
europepmc   +1 more source

Machine learning-based ground motion simulation for seismic hazard assessment of critical water infrastructure in Azerbaijan (Case study: Major Shamkir water reservoir). [PDF]

PLoS One
Babayev T, Babayev G, Bayramov E, Irawan S, Neafie J, Aliyeva S.   +5 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

A case study comparing anonymized and synthetic health insurance claims data for medication safety assessments. [PDF]

NPJ Digit Med
Halilovic M, Meurers T, Alibone M, Ludwig M, Tiwald P, Sieberg-Riedel N, Wolter S, Kühnel L, Hess S, Prasser F, Otte K.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Rapid LC-QTOF-MS screening method for semi-synthetic cannabinoids in whole blood. [PDF]

J Anal Toxicol
Schirmer W, Walton SE, Weinmann W, Schürch S, Logan BK, Krotulski AJ.   +5 more
europepmc   +1 more source