Results 251 to 260 of about 1,905,493 (317)

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Rethinking Trust in Synthetic Health Data: Lessons From 7 European Research Initiatives. [PDF]

J Med Internet Res
Declerck J, Kalra D, Airola A, Amer AYA, Chatzichristos C, Del Mar Mañu Pereira M, M de Brito Robalo B, Ghini F, Gutierrez-Torre A, Hoogteijling S, Hultsch S, Ramon J, Reidel S, Regazzoni F, Silva L, Silveira I, Sofia T, Maes C.   +17 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Scenario-Driven Synthetic Data Generation Framework for Visual Perception Evaluation Under Adverse Driving Conditions. [PDF]

Sensors (Basel)
Xu W, Gruyer D, Duminil A, Ieng SS.
europepmc   +1 more source

Timbre Encoding in the Inferior Colliculus. [PDF]

J Neurosci
Fritzinger JB, Carney LH.
europepmc   +1 more source

Editorial: Biomolecule production in plant synthetic biology. [PDF]

Front Plant Sci
Lee S, Kwon M.
europepmc   +1 more source

Integrating Genome-Scale Metabolic Modeling with Machine Learning Improves Gene Essentiality Prediction in Triple-Negative Breast Cancer. [PDF]

Int J Mol Sci
Kim BK, Gu C, Farh ME, Ryu JY.
europepmc   +1 more source

GLiNER-BioMed: a suite of efficient models for open biomedical named entity recognition. [PDF]

Bioinformatics
Yazdani A, Stepanov I, Teodoro D.
europepmc   +1 more source