Results 161 to 170 of about 2,952,613 (401)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Decoding protein binding plasticity via integrated deep ribosome display and deep learning

Communications Biology
The plasticity in protein interaction is central to understanding biological networks and de novo protein design. However, the systematic exploration remains impeded by the astronomic dimensionality of sequence space.
Mengtong Tang, Jiawei Li, Zhixi Li, Jingsong Cui, Hao Qi   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Synthetic and Systems Biology Approach towards Designing Metabolic Bypass and Identifying Novel Enzymes for Cholesterol Lowering Drug Precursor (BTO) Biosynthesis from Crude Glycerol [PDF]

, 2017
Dipankar Ghosh
openalex   +1 more source

Synthetic Biology: Emerging Concepts to Design and Advance Adeno‐Associated Viral Vectors for Gene Therapy

, 2021
Hanna J. Wagner, Wilfried Weber, Martin Fussenegger   +2 more
openalex   +1 more source

GUBS, a Behavior-based Language for Open System Dedicated to Synthetic Biology

, 2012
In this article, we propose a domain specific language, GUBS (Genomic Unified Behavior Specification), dedicated to the behavioral specification of synthetic biological devices, viewed as discrete open dynamical systems.
Adrien Basso-Blandin, Ashenden, Basu, Beal, Bilitchenko, Blackburn, Braüner, Cai, Calzone, Cerrito, Ciocchetta, Clancy, Czar, Danos, Delaplace, Franck Delaplace, Gabriel Ciobanu, Giavitto, Gibson, Hume, Lewis, Lu, Pedersen, Priami, Purnick, Regot, Thomas, Umesh, Ye   +28 more
core   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Microbes of traditional fermentation processes as synthetic biology chassis to tackle future food challenges [PDF]

, 2022
Adán Andrés Ramírez Rojas, Razan Swidah, Daniel Schindler   +2 more
openalex   +1 more source

BBF RFC 108: Synthetic Biology Open Language (SBOL) Version 2.0.0 [PDF]

, 2015
The Synthetic Biology Open Language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing ...
Bartley, Bryan, Beal, Jacob, Bissell, Michael, Clancy, Kevin, Gennari, John H., Madsen, Curtis, Misirli, Goksel, Myers, Chris, Nguyen, Tramy, Oberortner, Ernst, Pocock, Matthew, Roehner, Nicholas, Sauro, Herbert, Wipat, Anil, Zhang, Zhen   +14 more
core