Results 161 to 170 of about 2,683,742 (306)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Applications of synthetic biology in biomedicine. [PDF]

Mol Biomed
Li CX, Liu ZX, Lin YF, Wang ZH, Yang YM, Feng SY, Sun YH, Zhang XT, Fu W, Ding YF, Gao CC, Qin HY, Zhao JL.   +12 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

From Circuits to Symphonies: A Systems-Engineering Blueprint for Multimicrobial Synthetic Biology. [PDF]

Adv Sci (Weinh)
Fernández-Niño M, Wessjohann LA, Guillamón JM, Burgos-Toro D, Moriano-Gutiérrez S, Di Matteo G, Islam ZU, van van Tatenhove-Pel R, Rossetto Marcelino V, Ledesma-Amaro R.   +9 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Navigating regulatory fragmentation in the convergence of synthetic biology, artificial intelligence, and automation. [PDF]

Nat Commun
McLennan RKJ, Freemont PS, Pretorius IS.
europepmc   +1 more source

In Vitro Selection of Nucleic Acids with Complex Functionalities for Synthetic Biology Applications

, 2019
1
OH, SEUNG SOO
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Promise of Synthetic Biology for Redesigning Plant Architecture. [PDF]

Int J Mol Sci
Roychoudhry S, Dos Santos GD, Lloyd JPB.
europepmc   +1 more source

A comprehensive review of Microfluidic approaches in cell-free synthetic biology

Cell-free synthetic biology has gained increasing popularity owing to its ability to elucidate biological functions in isolation from intricate cellular environments and the capacity to build increasingly complex biochemical systems in vitro.
Maerkl, Sebastian, Baranwal, Amogh Kumar
core   +1 more source