Results 131 to 140 of about 25,449,411 (299)
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Exploring Synthetic Data, 2021-2022
In the UK, administrative data has helped us gain a picture of public service users and their needs. But administrative data contain personal and sensitive information which is important to protect so that individuals can never be identified.
Harron, K
core +2 more sources
Data hazards in synthetic biology
Synthetic BiologyAbstract Data science is playing an increasingly important role in the design and analysis of engineered biology. This has been fueled by the development of high-throughput methods like massively parallel reporter assays, data-rich microscopy techniques, computational protein structure prediction and design, and the development of whole ...
Natalie R Zelenka +9 more
openaire +3 more sources
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Algorithmic Generation of Parameterized Geometric Models of the Aortic Valve and Left Ventricle
SensorsSimulating the cardiac valves is one of the most complex tasks in cardiovascular modeling. As fluid–structure interaction simulations are highly computationally demanding, machine-learning techniques can be considered a good alternative. Nevertheless, it
Nikita Pil, Alex G. Kuchumov
doaj +1 more source
Efficacy of Synthetic Data as a Benchmark
CoRRLarge language models (LLMs) have enabled a range of applications in zero-shot and few-shot learning settings, including the generation of synthetic datasets for training and testing. However, to reliably use these synthetic datasets, it is essential to understand how representative they are of real-world data.
Gaurav Maheshwari 0005 +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
User-Centered Pipeline for Synthetic Augmentation of Anomaly Detection Datasets
ComputersAutomatic anomaly detection plays a critical role in surveillance systems but requires datasets comprising large amounts of annotated data to train and evaluate models. Gathering and annotating these data is a labor-intensive task that can become costly.
Alexander Rosbak-Mortensen +4 more
doaj +1 more source