Results 41 to 50 of about 242,186 (306)

Solar Contamination in Extreme-precision Radial-velocity Measurements: Deleterious Effects and Prospects for Mitigation [PDF]

, 2020
Solar contamination, due to moonlight and atmospheric scattering of sunlight, can cause systematic errors in stellar radial velocity (RV) measurements that significantly detract from the ~10 cm s−1 sensitivity required for the detection and ...
Bender, Chad F., Blake, Cullen H., Golub, Eli, Gupta, Arvind, Halverson, Samuel, Jaehnig, Kurt P., Kanodia, Shubham, Kaplan, Kyle, Logsdon, Sarah E., Mahadevan, Suvrath, McElwain, Michael W., Monson, Andrew, Ninan, Joe P., Rajagopal, Jayadev, Robertson, Paul, Roy, Arpita, Schwab, Christian, Stefansson, Gudmundur, Terrien, Ryan C., Wang, Sharon Xuesong, Wolf, Marsha J., Wright, Jason T.   +21 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Wet-Laid Nonwovens Manufacture – Chemical Approaches Using Synthetic and Cellulosic Fibers

BioResources, 2016
Wet-laid forming, which can be regarded as being analogous to conventional papermaking processes but with use of chopped synthetic or staple fibers, continues to draw attention as an advantageous way to prepare advanced nonwoven textile products.
Martin A. Hubbe, Alexander A. Koukoulas
doaj   +1 more source

Use of bamboo fiber in oil water separation [PDF]

, 2017
One of the environmental issues facing the society is the separation of oil from water in emulsions. Oily wastewater enters into the environment through many ways such as oil spill as well as from the industry.
Adhithya, N, Das, A, Goel, Mukesh
core  

Surface Modification of Melt Extruded Poly(ε-caprolactone) Nanofibers: Toward a New Scalable Biomaterial Scaffold. [PDF]

, 2014
A photochemical modification of melt-extruded polymeric nanofibers is described. A bioorthogonal functional group is used to decorate fibers made exclusively from commodity polymers, covalently attach fluorophores and peptides, and direct cell growth ...
Baer, Eric, Jordan, Alex M, Kim, Si-Eun, Korley, LaShanda TJ, Pokorski, Jonathan K, Wang, Jia   +5 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Direct Comparison of the Structural Compression Characteristics of Natural and Synthetic Fiber-Epoxy Composites: Flax, Jute, Hemp, Glass and Carbon Fibers

Fibers, 2020
Recent decades have seen substantial interest in the use of natural fibers in continuous fiber reinforced composites, such as flax, jute and hemp. Considering potential applications, it is of particular interest how natural fiber composites compare to ...
Mike R. Bambach
doaj   +1 more source