Results 51 to 60 of about 352,654 (215)
Deepfakes and Synthetic Media: Generation, Detection, and Governance
EncyclopediaDeepfakes, synthetic audiovisual content produced by deep generative models, have escalated into a critical threat across civilian and military domains, enabling identity fraud, disinformation campaigns, and evidence fabrication.
Alexandros Gazis +5 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Masalah-Masalah HukumThe rapid development of artificial intelligence (AI) has transformed various sectors, but it has also created serious challenges for child protection, particularly in the digital environment.
D. Sankar, Safoora Ahad
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Hakikat Sonrası Uçurumda Yön Bulmak: Sentetik Medya ve Yapay Zekanın İkili Kullanım İkilemi
Yeni MedyaBu çalışma, modern bilgi ekosisteminde üretken yapay zekanın ikili kullanımının doğasını örneklerle eleştirel bir şekilde ele almayı amaçlamaktadır. Yapay zeka, iletişim ve yaratıcılık manasında güçlü araçlar sunduğu gibi uydurma metinlerden derin kurgu (
Gökhan Varan
doaj
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Characterisation of the growth behaviour of Listeria monocytogenes in Listeria synthetic media. [PDF]
Environ Microbiol Rep, 2023 Schulz LM, Konrath A, Rismondo J.
europepmc +1 more source