Results 81 to 90 of about 352,654 (215)

Fake News Detection Through LLM-Driven Text Augmentation Across Media and Languages

Machine Learning and Knowledge Extraction
The proliferation of fake news across social media, headlines, and news articles poses major challenges for automated detection, particularly in multilingual and cross-media settings affected by data imbalance.
Abdul Sittar, Mateja Smiljanic, Alenka Guček, Marko Grobelnik   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Growth and Sporulation of Curvularia eragrostidis as Affected by Media and Nitrogen Sources

International Journal of Economic Plants, 2016
Out of eight synthetic and semi-synthetic solid and liquid culture media tested, host leaf extract agar and potato dextrose agar were the best semi-synthetic media for the growth of the Curvularia eragrostidis. Among liquid media, oat meal broth, potato
V. P. Prajapati, N. K. Gajre, D. H. Tandel, A. J. Deshmukh, R. C. Patel   +4 more
doaj  

Enhanced DeepFake Image Detection via Swin-B Transformer with Visual Attention Analysis

ITEGAM-JETIA
Deepfakes, synthetic media created using advanced machine learning techniques, pose significant societal challenges by spreading misinformation and undermining trust in media.
Vineela Krishna Suri, Prasad GVSNRV
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

DeepFake Image Detection using Swin Transformer with Attention-guided Feature Fusion and Explainable AI Techniques

ELCVIA Electronic Letters on Computer Vision and Image Analysis
Deepfakes, synthetic media created using advanced machine learning techniques, pose significant societal challenges by spreading misinformation and undermining trust in media.
Vineela Krishna Suri, G.V.S.N.R.V. Prasad   +1 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

13C-metabolic flux analysis of Saccharomyces cerevisiae in complex media

Metabolic Engineering Communications
Saccharomyces cerevisiae is often cultivated in complex media for applications in food and other biochemical production. However, 13C-metabolic flux analysis (13C-MFA) has been conducted for S.
Hayato Fujiwara, Nobuyuki Okahashi, Taisuke Seike, Fumio Matsuda   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source