Results 111 to 120 of about 4,808 (212)

Optical mapping: pioneering the frontier of preclinical antiarrhythmic drug evaluation. [PDF]

iScience
Li Y, Zheng Y, Dong R, Lin M, Chen T, Li J, Zhang R, Liu T, Tan X, Hao G, Ou X.   +10 more
europepmc   +1 more source

Automation and Active Learning for the Multi‐Objective Optimization of Antibody Formulations

Advanced Science, EarlyView.
Successful antibody formulation necessitates balancing factors such as thermal stability, colloidal stability, and viscosity across a vast excipient design space. This work integrates robotic liquid handling, high‐throughput biophysical characterization, and multi‐objective Bayesian optimization in an iterative closed‐loop Design‐Build‐Test‐Learn cycle.
D. Christopher Radford, Matthew Tamasi, Elena Di Mare, Adam J. Gormley   +3 more
wiley   +1 more source

Advanced Imaging for Live-Cell Spatiotemporal Monitoring: Technologies and Applications. [PDF]

Research (Wash D C)
Zhuang Z, Feng Z, Wang J, Liu X, Song L, Sun C, Liu H, Ren N.   +7 more
europepmc   +1 more source

Cation Diffusion‐Mediated Displaced Reaction‐Transformation in Green Steelmaking

Advanced Science, EarlyView.
The removal of O lattice atoms by environmental H2 at the surface of Fe3O4 results in Fe enrichment, driving the inward diffusion of Fe cations into the bulk. Through hopping between unoccupied and initially occupied sites, cation diffusion triggers a spatially displaced reaction‐transformation and drives subsequent dynamic phase transformations and ...
Guangyi Guo, Paul Paciok, Baptiste Bienvenu, Longqi Bai, Barak Ratzker, Marc Heggen, Xuyang Zhou, Dierk Raabe   +7 more
wiley   +1 more source

Functional super-resolution microscopy of fibers and polymers: convergence of artificial and biological systems at the nanoscale.

Nanoscale Horiz
Rao SJ, Gong X, Shahid MA, Liu Y, Mao H, Zhang Y.   +5 more
europepmc   +1 more source

Super-Resolution Microscopy as a Versatile Tool in Probing Molecular Assembly. [PDF]

Int J Mol Sci
Sun N, Bai S, Dai L, Jia Y.
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Deep learning in chromatin organization: from super-resolution microscopy to clinical applications. [PDF]

Cell Mol Life Sci
Rotkevich M, Viana C, Neguembor MV, Cosma MP.   +3 more
europepmc   +1 more source

Pattern‐Aware Intelligence Enables Nondestructive, Rapid Quantification of High‐Aspect‐Ratio Silicon Etching

Advanced Science, EarlyView.
Pattern‐dependent etching is converted into a physical prior for intelligent reconstruction of high‐aspect‐ratio silicon structures. Combining YOLO‐Pose feature extraction with a topography network, the framework retrieves depth, sidewall angle, and scallop texture from minimal destructive observations, enabling accurate cross‐scale metrology and near ...
Shuyan He, Lang Chen, Bo Wen, Yufeng Jin, Wei Wang   +4 more
wiley   +1 more source

Barriers and facilitators to dengue prevention strategies in Bangladesh: a scoping review with comparative analysis of other dengue-prone regions. [PDF]

BMC Infect Dis
Rahman L, Goutam A, Masud SB, Eva FN, Mostofa MM, Islam T, Hawlader MDH.   +6 more
europepmc   +1 more source