Results 41 to 50 of about 156,644 (276)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Prevention of congenital syphilis: The current state of legislation and public health guidelines

Pregnancy
Syphilis infection among pregnant people and congenital syphilis rates have risen considerably in the United States, leading to adverse maternal and neonatal health outcomes.
Rose Darcy, Laurie Ayala, Maura Quinlan, Danucha Brikshavana, Anne Statton, Irina Tabidze, Helen Cejtin, Jennifer Jao, Sarah Sutton, Nigel Madden, Mariana Espinal, Lynn M. Yee   +11 more
doaj   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Evaluating the MedMira Multiplo® Complete Syphilis (TP/nTP) antibody test in a sexually transmitted infection clinic in Ottawa, Canada: increased rapid diagnosis and improved antibiotic stewardship

BMC Infectious Diseases
Background Syphilis now affects every population and serology is the mainstay of diagnosis. The issue is that serology has a turnaround time of several days. One solution is point-of-care tests (POCTs), which can provide results in minutes.
Patrick O’Byrne, Riley Dillabough, Kathleen Whyte, Lauren Orser, Vanessa Tran, Venkata R. Duvvuri, Raymond Tsang   +6 more
doaj   +1 more source

MONITORING OF SYPHILIS IN BLOOD DONATIONS: CORRELATIONS WITH NOTIFIED CASES IN BRAZIL

Hematology, Transfusion and Cell Therapy
Background: Syphilis is a public health problem with traditional surveillance limited to clinical monitoring data; asymptomatic and low-risk populations rarely undergo diagnostic testing.
NA Braga, S Mateos, V Avelino-Silva, D Warden, M Ribeiro, L Amorim, P Loureiro, N Fraiji, EC Sabino, B Custer   +9 more
doaj   +1 more source

Psoriasiform syphilis: a challenge

Dermatology Reports, 2021
Syphilis is one of the greatest masqueraders in dermatology, like mycosis fungoides or sarcoidosis. In fact, secondary syphilis can simulate different dermatological conditions, not only clinically but also histopathologically.
Antônio Pedro Schettini, José Carlos Sardinha, Elyana Almeida Marques, Cesare Massone   +3 more
doaj   +1 more source

Blood‐Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications

AGING MEDICINE, EarlyView.
Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley   +1 more source

The prevalence of vertical transmission of human immunodeficiency virus and associated factors among exposed infants in Eastern Lake zone and Southern Highland of Tanzania: a cross-sectional study

HIV Research & Clinical Practice
Background Globally, the rate of antiretroviral therapy coverage for pregnant women living with human immunodeficiency virus (HIV) increased by 38% between 2010 and 2015 but only by 2% between 2016 and 2020.
Peter Richard Torokaa, Loveness Urio, Ambwene Mwakalobo, Godfrey Eriyo, Alex Sifael Magesa, Regnald Julius, Alice Kyalo, James N. Allan, David J. Osima, Focus M. Shao, Joseph Mziray, Leah Mtui, Theopista P. Mbago, Masanja Robert, Mukome A. Nyamhagatta, Michael Msangi, Maro Chacha, Hasra Charles, Grace Denis Mtui, Mtebe Majigo, Agricola Joachim   +20 more
doaj   +1 more source

Cerebral Hemodynamic Changes in Older Adults With Cognitive Complaints According to the Presence of Peripheral Artery Disease

AGING MEDICINE, EarlyView.
Among 132 older adults, 13 had peripheral artery disease (PAD), identified using the ankle–brachial index. Over approximately 13 months, PAD was associated with increasing middle cerebral artery mean flow velocity, with a significant difference in left‐sided velocity change between groups.
SangMi Noh, Hae‐Eun Shin, YongSoo Shim
wiley   +1 more source

Clinical and immunological characteristics of HIV/syphilis co-infected patients following long-term antiretroviral treatment

Frontiers in Public Health
ObjectiveThis study aims to analyze the efficacy of anti-syphilis treatment and the impact of syphilis events on HIV virology and immunology in HIV/syphilis co-infected patients on long-term antiretroviral therapy (ART) and to investigate the incidence ...
Yuanni Wu, Lianfeng Lu, Xiaojing Song, Xiaosheng Liu, Yang Yang, Ling Chen, Jia Tang, Yang Han, Wei Lv, Wei Cao, Taisheng Li, Taisheng Li, Taisheng Li   +12 more
doaj   +1 more source