Results 191 to 200 of about 19,151 (222)

Extracellular fluid viscosity influences the mechanics and migration of MDA‐MB‐231 cells in a macromolecule‐dependent manner

The FEBS Journal, EarlyView.
Macromolecule‐dependent increases in extracellular fluid viscosity alter cell phenotype. These distinct macromolecules create different extracellular environments that modulate cell morphology and mechanoprotein expression, migration and invasion capacity, and cellular mechanical properties.
Ian M. Smith, Nikka Givpoor, Chenchen Handler, Ariel Abraham, Shohini Banerjee, Giuliano Scarcelli, Kimberly M. Stroka   +6 more
wiley   +1 more source

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

The FEBS Journal, EarlyView.
Athe_2052 is an ABC transporter substrate‐binding protein that recognizes xyloglucan heptasaccharide (XXXG), a soluble breakdown product of plant xyloglucan. The crystal structure of Athe_2052, together with binding assays and computational modeling, shows how XXXG is recognized by this sugar transporter.
Hansen Tjo, Virginia Jiang, Philip D. Jeffrey, Angela Zhu, A. James Link, Jerelle A. Joseph, Jonathan M. Conway   +6 more
wiley   +1 more source

Triple Oxygen Isotope Compositions of Isotopic Reference Waters: Implications for VSMOW‐Scale and VSMOW–SLAP‐Scale Δ′17O Calibration

Geostandards and Geoanalytical Research, EarlyView.
Key Points Triple oxygen isotope ratios of two primary (VSMOW, SLAP) and twelve secondary water isotopic reference materials were precisely measured using BrF5 fluorination‐IRMS. The measured Δ'17OVSMOW value for SLAP (34 ± 6 per meg) demonstrates that VSMOW‐SLAP normalisation ensures interlaboratory comparability, but introduces systematic offsets for
Ryoji Tanaka, Andreas Pack, Tyler B. Coplen   +2 more
wiley   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Radiographic Intraradicular Reduction of a Calcium Silicate–Based Sealer: Case Reports

International Endodontic Journal, EarlyView.
ABSTRACT Aim To document radiographically observable intraradicular reduction of AH Plus Bioceramic, a premixed calcium silicate–based sealer (CSBS), during clinical follow‐up after nonsurgical root canal retreatment. Summary Four cases of nonsurgical root canal retreatment performed with a premixed CSBS using a single‐cone obturation technique are ...
Damien Savoure, Nadia Mayorova, Camille Lufeaux, Constance Ambroise   +3 more
wiley   +1 more source

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End‐of‐Life Palliative Care

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Daiping Li, Yanwu Yang, Yan Zhang, Jirong Yue, Birong Dong, Meiling Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +7 more
wiley   +1 more source

A Hidden History of Unhappiness

Critical Quarterly, EarlyView.
Joe Moran
wiley   +1 more source

6‐Month Clinical Evaluation of Reduced Dentin Etching Time Using Universal Adhesives in Noncarious Cervical Lesions: A Double‐Blind Randomized Clinical Trial

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objectives To evaluate the effect of reduced dentin etching time on the clinical performance of two universal adhesive systems in noncarious cervical lesions (NCCLs). Methods A total of 144 NCCLs restorations were randomly placed in 36 participants according to four experimental groups: SUP5 (Scotchbond Universal Plus adhesive [pH ≈2.5–2.7 ...
Mario Felipe Gutiérrez, Natalia Amo‐Nicolás, Alondra Beniscelli‐Vásquez, Romina Aliaga‐Gálvez, Alessandro D. Loguercio   +4 more
wiley   +1 more source

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Correlates of disparities in syringe return ratios: A cross-sectional study of a syringe services program in New York

Journal of Substance Abuse Treatment, 2021
Predictors of syringe exchange behavior are critical to informing secondary prevention measures needed to attenuate risk of blood-borne infections among persons who inject drugs (PWID).Participants included PWIDs who attended a syringe services program in New York from 2015 to 2017 (n = 1777).
, Roger S Zoh, Maria A Parker
exaly   +3 more sources

A Syringe Service Program Within a Federal System

Journal of Addictions Nursing, 2021
Abstract Background Drug use, specifically opioid use, is a public health crisis in the United States. Harm reduction programs, including syringe service programs, show efficacy in improving individual and public health outcomes.
Rebecca D. Lynch, Donna J. Biederman, Susan Silva, Kim Demasi   +3 more
openaire   +2 more sources