Results 141 to 150 of about 4,288 (259)

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

open access: yesPediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu   +4 more
wiley   +1 more source

DEET‐cyclodextrin inclusion complexes for mosquito and tick repellency: Extended repellency time and no zebrafish embryotoxicity

open access: yesPest Management Science, EarlyView.
Hydroxypropyl‐β‐cyclodextrin (HPβCD)–N,N‐diethyl‐meta‐toluamide (DEET) complex extended tick repellency to 168 h. Full protection against Aedes aegypti for 7 h with HPβCD‐DEET. HPβCD reduced DEET release and skin retention significantly. No embryotoxicity observed below 325 mg L−1 in zebrafish model.
Gessyka Rayana Silva Pereira   +10 more
wiley   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

open access: yesPhytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee   +9 more
wiley   +1 more source

Seasonal Variation in Carbon Dynamics in the Lower Tocantins River: Influence of Discharge and Environmental Drivers

open access: yesRiver Research and Applications, EarlyView.
ABSTRACT Tropical rivers play a key role in regional carbon budgets, yet greenhouse gas (GHG) dynamics in regulated systems remain poorly understood. This study investigates the seasonal variability of carbon dioxide (CO2) and methane (CH4) concentrations, isotopic composition (δ13C), and river‐atmosphere fluxes in the lower Tocantins River, a ...
Maria Gabriella da S. Araújo   +5 more
wiley   +1 more source

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