Results 101 to 110 of about 16,129,052 (298)
Are Innovation Systems Complex Systems?
, 2016 Basically, complex systems are defined as a large number of autonomous entities in interaction, that create several levels of collective organization leading to emergent (and immergent) behavior. In short, complex systems are characterized by the observation that the whole is more than the sum of the parts (Aristotle).
Muller, Emmanuel +2 more
openaire +3 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Nauka ta progres transportu, 2008 In the paper the analysis of functioning conditions of existing management system of Derzhspetstranssluzhba (State Special Service of Transport) is conducted with the purpose of improvement of its functioning efficiency.
O. O. Stepanenko
doaj
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
A Contribution to Ultrasound Preparation of Hard Dental Tiss
Česká Stomatologie a Praktické Zubní Lékařství, 2005 Objective: The aim of the work was to compare the effect of the system Vector® (Dürr Dental, Germany) and classical rotation technique in the preparation of cavities. Methods: The experiment was performed on extracted teeth.
L. Roubalíková
doaj
The impact of ongoing armed conflict on Sudan’s healthcare system: narrative review [PDF]
Babiker Rahamtalla +9 more
openalex +1 more source