Results 111 to 120 of about 19,008,149 (295)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Multivariate Analysis, Retrieval, and Storage System (MARS). Volume 1: MARS System and Analysis Techniques [PDF]

A method for rapidly examining the probable applicability of weight estimating formulae to a specific aerospace vehicle design is presented. The Multivariate Analysis Retrieval and Storage System (MARS) is comprised of three computer programs which ...
Hague, D. S., Vanderberg, J. D., Woodbury, N. W.   +2 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Achieving net zero greenhouse gas emissions critical to limit climate tipping risks

Nature Communications
Under current emission trajectories, temporarily overshooting the Paris global warming limit of 1.5 °C is a distinct possibility. Permanently exceeding this limit would substantially increase the probability of triggering climate tipping elements.
Tessa Möller, Annika Ernest Högner, Carl-Friedrich Schleussner, Samuel Bien, Niklas H. Kitzmann, Robin D. Lamboll, Joeri Rogelj, Jonathan F. Donges, Johan Rockström, Nico Wunderling   +9 more
doaj   +1 more source

The space physics environment data analysis system (SPEDAS) [PDF]

, 2019
With the advent of the Heliophysics/Geospace System Observatory (H/GSO), a complement of multi-spacecraft missions and ground-based observatories to study the space environment, data retrieval, analysis, and visualization of space physics data can be ...
Angelopoulos, V., Cruce, P., Drozdov, A., Grimes, E. W., Hatzigeorgiu, N., King, D. A., Larson, D., Lewis, J. W., McTiernan, J. M., Roberts, D. A., Walsh, Brian M.   +10 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Data-driven combination of METAR observations and CAMS reanalysis aerosols to enhance satellite retrieval of surface solar irradiance

Scientific Reports
Accurate solar irradiance forecasts are vital for photovoltaic (PV) power prediction, especially in tropical and subtropical regions affected by dust, wildfire smoke, and pollution.
Arindam Roy, Detlev Heinemann, Marion Schroedter-Homscheidt, Jorge Enrique Lezaca Galeano   +3 more
doaj   +1 more source

Peak Analysis System [PDF]

Science, 1973
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source