System Change, Not Climate Change
, 2022 The latest IPCC reports have concluded that in order to limit warming to 1.5°C, system transformations are urgently needed. But what are system transformations? How can they be enabled? Wouldn’t such system transitions worsen other social and environmental challenges? How can justness be safeguarded during transitions?
openaire +3 more sources
The Pervasiveness of Power: Dilemmas for Researchers of Major System Change in Healthcare Comment on "'Attending to History' in Major System Change in Healthcare in England: Specialist Cancer Surgery Service Reconfiguration". [PDF]
Int J Health Policy Manag, 2023 Smith CQ, Williams I.
europepmc +1 more source
Change, rigidity & delay in the UK system of land-use development control [PDF]
, 2008 The British system of development control is time-consuming and uncertain in outcome. Moreover, it is becoming increasingly overloaded as it has gradually switched away from being centred on a traditional ‘is it an appropriate land-use?’ type approach to
Allmendinger, Philip Michael +1 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
, 2023 This dissertation explores how we can better understand and influence systems, which are collections of interrelated or interacting elements that are organized in a way to achieve something. Systems are everywhere, from the global economy and natural ecosystems to mental health and the spread of infectious diseases, and they can be understood from ...
openaire +1 more source
The Montado agroforestry system microclimatic specificity in the context of global change [PDF]
, 2009 The effects of oak trees on microclimatic parameters in Quercus rotundifolia Lam. woodland in the Alentejo, Southern Portugal, are reported. Results show that oak tree create a marked differentiation in the grass matrix, between open and undercanopy ...
Abreu, Francisco +4 more
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Demographic Change and Public Sector Budgets in a Federal System [PDF]
This paper examines the effects of demographic change on public finances in a federal system. We develop a simple methodical procedure to measure the effect of demographic changes on public revenues and expenditures.
Gerhard Kempkes +2 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Delivering and sustaining change through implementation of a lean management system : a journey towards health improvement : a thesis presented in partial fulfilment of the requirements for the degree of Master of Business Studies in Management at Massey University, Albany, New Zealand [PDF]
, 2017 In this ever-changing world organisations seek to be adaptive and innovative and in response they are adopting new ways of working. Approaches to managing change have been well documented and have progressed as a deeper understanding of change and the ...
Winstone, Tim
core