Results 181 to 190 of about 12,384,515 (284)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Game changing electoral reforms and party system change? An analysis of the 2020 national assembly election in South Korea. [PDF]

Heliyon
Saxer CJ.
europepmc   +1 more source

UK Healthcare Workers' Experiences of Major System Change in Elective Surgery During the COVID-19 Pandemic: Reflections on Rapid Service Adaptation. [PDF]

Int J Health Policy Manag, 2022
Singleton G, Dowrick A, Manby L, Fillmore H, Syverson A, Lewis-Jackson S, Uddin I, Sumray K, Bautista-González E, Johnson G, Vindrola-Padros C.   +10 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Highly Sensitized Kidney Transplant Outcomes After the 2014 Kidney Allocation System Change. [PDF]

Prog Transplant
Chang JH, King KL, Ali Husain S, Dube GK, Rodica Vasilescu E, Patel S, Cohen DJ, Ratner LE, Mohan S, John Crew R.   +9 more
europepmc   +1 more source

Implementing major system change in specialist cancer surgery: The role of provider networks. [PDF]

J Health Serv Res Policy, 2021
Vindrola-Padros C, Ramsay AI, Perry C, Darley S, Wood VJ, Clarke CS, Hines J, Levermore C, Melnychuk M, Moore CM, Morris S, Mughal MM, Pritchard-Jones K, Shackley D, Fulop NJ.   +14 more
europepmc   +1 more source

Effects of climate change on the Flemish water system (Belgium) [PDF]

, 2009
De Sutter, Renaat, Ingle, Ruchita
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evaluating Competence by Design as a Large System Change Initiative: Readiness, Fidelity, and Outcomes. [PDF]

Perspect Med Educ
Hall AK, Oswald A, Frank JR, Dalseg T, Cheung WJ, Cooke L, Gorman L, Brzezina S, Selvaratnam S, Wagner N, Hamstra SJ, Van Melle E.   +11 more
europepmc   +1 more source

Cost-Utility Analysis of Major System Change in Specialist Cancer Surgery in London, England, Using Linked Patient-Level Electronic Health Records and Difference-in-Differences Analysis. [PDF]

Appl Health Econ Health Policy, 2022
Clarke CS, Melnychuk M, Ramsay AIG, Vindrola-Padros C, Levermore C, Barod R, Bex A, Hines J, Mughal MM, Pritchard-Jones K, Tran M, Shackley DC, Morris S, Fulop NJ, Hunter RM.   +14 more
europepmc   +1 more source