Results 181 to 190 of about 25,813,097 (311)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Arts District Foundation and Artpicks—City Arts Program presents Voices of Change

, 1985
A concert recording of the July 20, 1985 performance of the Voices of Change music ensemble. The Voices of Change music ensemble performs works by 20th and 21st century composers.
Voices of Change (Musical group)
core  

Centering marginalized care: Home care cooperatives and system change. [PDF]

Health Aff Sch
Gusoff GM, Stepick L, Soriano-Versoza A, Kazda K.   +3 more
europepmc   +1 more source

From patient outcomes to system change: Evaluating the impact of VHA's implementation of the Whole Health System of Care. [PDF]

Health Serv Res, 2022
Bokhour BG, Hyde J, Kligler B, Gelman H, Gaj L, Barker AM, Douglas J, DeFaccio R, Taylor SL, Zeliadt SB.   +9 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Transformative capacities for navigating system change: a framework for sustainability research and practice. [PDF]

Sustain Sci
Orr CJ, Burch S.
europepmc   +1 more source

Can Labelling Create Transformative Food System Change for Human and Planetary Health? A Case Study of Meat. [PDF]

Int J Health Policy Manag, 2021
Parker C, Carey R, Haines F, Johnson H.
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Practical strategies for achieving system change in the US: lessons and insights from the CONQUEST quality improvement programme. [PDF]

Prim Health Care Res Dev
Evans A, VanWyk J, Kerr M, Couper A, Pace WD, Tarabichi Y, Pullen R, Pollack M, Drummond MB, Ohar J, Meldrum C, Han MK, Kaplan A, Winders T, Wisnivesky J, Make B, Federman A, Carter V, Lang K, Mapel D, Hanania NA, Stolz D, Martinez FJ, Price D.   +23 more
europepmc   +1 more source

Children and Young People's Health Partnership Evelina London Model of Care: economic evaluation protocol of a complex system change. [PDF]

BMJ Open, 2021
Soley-Bori M, Lingam R, Satherley RM, Forman J, Cecil L, Fox-Rushby J, Wolfe I.   +6 more
europepmc   +1 more source